Unexpected Isolation of 4‐Isothiocyanatomethylene‐4H‐pyridine‐1‐carboxylic Acid Ethyl Ester as Potential Template in Organic Synthesis.

Abstract

Synthesis. -Optimized syntheses of 4-isothiocyanatomethylpyridine (IX) and title ester (VI), side product in the original synthesis of (IX), are developed. Both compounds appear to be appropriate precursors for the preparation of thiourea derivative (VIII). -(SARHAN*, A. E.; JOERGENSEN, P. T.; PEDERSEN, E. B.; Synth. Commun. 35 (2005) 18, 2475-2480; Dep. Med.