Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases

Lopera, Esteban; Baena, Armando; Flórez, Víctor; Montiel, Jehidys; Duque, Constanza; Ramírez, Tatiana; Borrero, Mauricio; Córdoba, C.; Rojas, Fredy; Pareja, René; Bedoya, Astrid Milena; Bedoya, Gabriel; Sánchez, Gloria Inés

doi:10.1016/j.meegid.2014.10.014

Cited by 21 publications

(21 citation statements)

References 55 publications

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“…However, it is important to take into account that a direct association between the human ancestry and HPV lineage is not necessarily expected in a population with ethnic admixture and with individuals having different proportions of genetic ancestry. This fact was reported by Lopera et al [] analyzing women with cervical cancer that presented an inverse correlation between infections by HPV16 lineage D (common in Native American population) with the higher proportion of informative genetic markers (AIMs) from Native American ancestry. To better understand this finding it is required to analyze the prevalence of these lineages in women without cancer, because the current prevalence in invasive cancer might be associated with differences of their carcinogenic potential in the studied population.…”

Section: Discussionmentioning

confidence: 58%

“…Few Brazilian studies have studied HPV16 and HPV18 intra‐type variants [Villa et al, ; Cruz et al, ; Sichero et al, ; Cerqueira et al, ; Junes‐Gill et al, ; Sichero et al, ; Freitas et al, ], and almost no studies have investigated samples obtained from invasive cancer [Junes‐Gill et al, ]. Interest in HPV16 and HPV18 intra‐type diversity has been increasing in recent years due to reports suggesting an interaction between host and viral characteristics influencing the natural history of infection and the prognosis of lesions at different stages [de Araujo Souza et al, , ; Lopera et al, ].…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

Vidal

Felix

Chaves

et al. 2016

Journal of Medical Virology

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Cervical cancer is the fourth most common cancer among women, and ∼70-80% of these cancers are associated with two human papillomavirus types: HPV16 and HPV18. Several studies have reported that intra-type diversity is associated with the progression of infection to invasive cancer. Herein, we report the genetic diversity of HPV16 and HPV18 in a cohort of 594 Brazilian women with invasive cervical cancer and describe the prevalence of lineages and intra-type diversity prior to the implementation of the public immunization program in Brazil. HPV detection and genotyping were performed using PCR, PGMY/GP primers, and DNA extracted from fresh tumors. The HPV16 (378 women) and HPV18 (80 women) lineages were identified by PCR and sequencing of the LCR and E6 fragments, followed by SNV comparison and phylogenetic analysis. In our cohort, was found a higher frequency of the lineage A (in 217 women), followed by lineage D (in 97 women) and lineages B and C (in 10 women each) for HPV16; and a higher frequency of lineage A (in 56 women) followed by lineage B (in 15 women) in HPV18. The genetic diversity of HPV16 indicated a recent expansion of specific variants or a selective advantage that is associated with invasive cancer; this pattern was not observed for HPV18.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

Vidal

Felix

Chaves

et al. 2016

Journal of Medical Virology

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“…Possible mechanisms related to the immune response enable better elimination of infection by certain variants in specific populations [25, 26]. Evidence has been presented that genetic differences between racial groups might explain the functional diversity of immune response factors, inflammation, metabolism, etc., in response to HPV infection [27].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

et al. 2016

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This study reports six HR-HPV types’ infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12–19 year-old females using conventional generic and type-specific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01–2.71 95%CI), white ethnicity (4.40: 1.16–16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11–2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17–2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18–0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.

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“…Samples analyzed in this study stem from a formalin-fixed paraffin-embedded (FFPE) sample repository from the Catalan Institute of Oncology (ICO), Barcelona, Spain, designed and constructed for the assessment of HPVs contribution to a number of anogenital human tumors [4,6,[8][9][10]. All samples were tested for the presence of tumor tissue and for the presence of HPVs DNA using the SPF 10 -LiPA 25 protocol, capable of genotyping HPV6, 11,16,18,31,33,34,35,39,40,42,43,44,45,51,52,53,54,56,58,59,66,68,70, and 74 (version 1; Laboratory Biomedical Products, Rijswijk, the Netherlands). For this study, we selected 711 invasive squamous cell carcinomas showing exclusively the presence of HPV16 DNA after LiPA 25 genotyping.…”

Section: Samplesmentioning

confidence: 99%

HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus

et al. 2016

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Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus‐induced anogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages present in 692 HPV16‐monoinfected invasive anogenital cancers from Europe, Asia, and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distribution of HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1‐3, except in Asia, where HPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accounted for less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties). Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenital cancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1‐3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.

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Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases

Cited by 21 publications

References 55 publications

Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus

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