Unexpected Intraparenchymal Hematoma Caused by Brain Metastasis in a Patient With Neuroblastoma  -Case Report-

Okura, Hidehiro; Yatomi, Kenji; Saito, Youhei; Kasuga, Chinatsu; Ishii, Hisato; Karagiozov, Kostadin; Miyajima, Masakazu; Arai, Hajime

doi:10.2176/nmc.51.784

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…In our setting, we found patients who either had no clinical symptoms and relapse was found on routine imaging (two patients) or who had severe neurological symptoms of bleeding and invagination was the first clinical presentation (four patients). Intraparenchymal haematoma occurring prior to radiologically detectable CNS metastases are rarely described in the literature [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group

et al. 2022

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Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the presentation and assessment of the incidence and clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centres of the Polish Paediatric Solid Tumours Study Group (PPSTSG). Group characteristics at diagnosis, treatment and patterns of relapse were analysed. Observation was completed in December 2020. We analysed 286 high risk patients, including 16 infants. Isolated CNS relapse, defined as the presence of a tumour in brain parenchyma or leptomeningeal involvement, was found in 13 patients (4.5%; 8.4% of all relapses), all of whom were stage 4 at diagnosis. Isolated CNS relapses seem to be more common in young patients with stage 4 MYCN amplified NBL, and in this group they may occur early during first line therapy. The only or the first symptom may be bleeding into the CNS, especially in younger children, even without a clear relapse picture on imaging, or the relapse may be clinically asymptomatic and found during routine screening. Although the incidence of isolated CNS relapses is not statistically significantly higher in patients after immunotherapy, their occurrence should be carefully monitored, especially in intensively treated infants, with potential disruption of the brain-blood barrier.

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Section: Discussionmentioning

confidence: 99%

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group

et al. 2022

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“…Another example is a 2‐year‐old female with a history of stage IV neuroblastoma who presented with a generalized seizure, headache, and vomiting found to have right temporal hematoma. The hematoma was removed, but 4 weeks later, MRI brain showed a right temporal mass that was consistent with metastatic neuroblastoma …”

Section: Brain Tumor Headache In General and The Ichdmentioning

confidence: 99%

Headaches in Brain Tumor Patients: Primary or Secondary?

Nelson

Taylor

2014

Headache

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Our literature review revealed that brain tumor headache uncommonly presents with classic brain tumor headache characteristics and often satisfies criteria for a primary headache category such as migraine or tension-type. Thus, clinicians may miss headaches due to brain tumors in following ICHD-3 criteria, and the distinction between primary and secondary headache disorders may not be so clear-cut.

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“…The intraparenchymal hematoma occurring prior to radiologically detectable CNS metastases are rarely described in the literature 34 .…”

Section: Discussionmentioning

confidence: 99%

Isolated central nervous system relapses in patients with high-risk neuroblastoma. Clinical presentation and prognosis: experience of the Polish Pediatric Solid Tumors Study Group.

Wieczorek¹,

Stefanowicz²,

Hennig³

et al. 2021

Preprint

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Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of the study is presentation, assessment of incidence and the clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centers of the Polish Pediatric Solid Tumors Study Group (PPSTSG). Group characteristics at diagnosis, treatment and patterns of relapse were analyzed. Observation was completed in December 2020. We analyzed 286 high risk patients, including 16 infants. Isolated CNS relapse, defined as presence of a tumor in brain parenchyma or leptomeningeal involvement, was found in 13 patients (4.5%, 8.4% of all relapses), all of them were stage 4 at diagnosis. Isolated CNS relapses seem to be more common in young patients with stage 4 MYCN amplified NBL, and in this group they may occur early during the first line therapy. The only or the first one symptom may be bleeding into CNS, especially in younger children, even without clear relapse picture on imaging, or the relapse may be clinically asymptomatic and found on routine screening. Although incidence of isolated CNS relapses is not statistically significantly higher in patients after immunotherapy, their occurrence should be carefully monitored, especially in intensively treated infants, with potential disruption of brain-blood barrier.

show abstract

Unexpected Intraparenchymal Hematoma Caused by Brain Metastasis in a Patient With Neuroblastoma -Case Report-

Cited by 4 publications

References 25 publications

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group

Headaches in Brain Tumor Patients: Primary or Secondary?

Isolated central nervous system relapses in patients with high-risk neuroblastoma. Clinical presentation and prognosis: experience of the Polish Pediatric Solid Tumors Study Group.

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