Unexpected concomitant pituitary adenoma and suprasellar meningioma: a case report and review of the literature

Vries, Friso de; Lobatto, Daniel J.; Najafabadi, Amir H Zamanipoor; Kleijwegt, Maarten; Verstegen, Marco J. T.; Schutte, Pieter J.; Biermasz, Nienke R.; Furth, Wouter R. van

doi:10.1080/02688697.2018.1556782

Cited by 12 publications

(25 citation statements)

References 40 publications

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“…Simultaneous occurrence of pituitary adenoma and meningioma without a history of radiotherapy is a rare condition clinically, having only been described in 49 cases before 2019, 9 while ACTH-secreting pituitary adenomas (CD) comorbid with meningioma have been reported even less frequently. In the reported cases, the most common site of meningioma is parasellar, accounting for 44.9%, while meningioma located in the distant part of the adenoma is rare.…”

Section: Discussionmentioning

confidence: 99%

“…In the reported cases, the most common site of meningioma is parasellar, accounting for 44.9%, while meningioma located in the distant part of the adenoma is rare. 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…Gene mutations are a common molecular characteristic of meningiomas, with inactivation of the neurofibromatosis type 2 (NF2) tumor suppressor gene found in 55% of meningiomas, and a further 25% of meningiomas accounted for by recently described mutations in other genes. 8 Simultaneous occurrence of pituitary adenoma and meningioma without a history of radiotherapy is a rare condition clinically, having only been described in 49 cases before 2019, 9 while ACTH-secreting pituitary adenomas (CD) comorbid with meningioma have been reported even less frequently. In the reported cases, the most common site of meningioma is parasellar, accounting for 44.9%, while meningioma located in the distant part of the adenoma is rare.…”

Section: Pituitary Adenoma Associated With Meningiomamentioning

confidence: 99%

“…In the reported cases, the most common site of meningioma is parasellar, accounting for 44.9%, while meningioma located in the distant part of the adenoma is rare. 9,10 A number of clinicians have suggested that the coexistence of meningiomas and pituitary adenomas is incidental, with no relationship between the two diseases. 2,11 Genetic imbalances have been found in pituitary adenomas, including in particular the chromosomal deletions of 1p, 2q, 4, 5, 6, 11q, 12q, 13q, and 18q, and the overexpression of 9q, 16p, 17p, 19, and 20q.…”

Section: Pituitary Adenoma Associated With Meningiomamentioning

confidence: 99%

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<p>Cushing’s Disease Caused by a Pituitary Microadenoma Coexistent with a Meningioma: A Case Report and Literature Review</p>

Wang¹,

Sun²,

Jiang³

2020

IJGM

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Cushing's disease (CD), also known as adrenocorticotropic hormone (ACTH)dependent pituitary Cushing's syndrome, is a rare and serious chronic endocrine disease that is usually caused by a pituitary adenoma (especially a pituitary microadenoma). Meningioma is the most common type of primary intracranial tumor and is usually benign. The patient in this case report presented with CD coexisting with pituitary microadenoma and meningioma, which is an extremely rare comorbidity. The pathogenesis of CD associated with meningioma remains unclear. Here, we describe the case of bilateral lower extremity edema, lower limb pain, abdominal purplish striae, and abdominal distension for 9 months in a 47-year-old woman. Two years ago, the patient underwent a hysterectomy at a local hospital for hysteromyoma. She had no previous radiotherapeutic treatment or other medical history. Magnetic resonance imaging of her head revealed a sellar lesion (7.8 mm × 6.4 mm) and a spherical mass (3.0 cm × 3.0 cm) in the right frontal convexity. Her level of serum adrenocorticotropic hormone (ACTH) was 169 pg/mL, and her cortisol levels were 933 nmol/mL and 778 nmol/mL at 8 am and 4 pm, respectively. Preoperatively, she was diagnosed with ACTH-secreting pituitary microadenoma and meningioma. Excision of the meningioma was performed through a craniotomy, while an endoscopic endonasal transsphenoidal approach was used to remove the pituitary adenoma. Meningioma and pituitary adenoma were confirmed by postoperative pathology. On the basis of this unusual case, the relevant literature was reviewed to illustrate the diagnosis and treatment of Cushing's disease and to explore the pathogenesis of pituitary adenoma associated with meningioma.

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Section: Discussionmentioning

confidence: 99%

“…In the reported cases, the most common site of meningioma is parasellar, accounting for 44.9%, while meningioma located in the distant part of the adenoma is rare. 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

Section: Pituitary Adenoma Associated With Meningiomamentioning

confidence: 99%

Section: Pituitary Adenoma Associated With Meningiomamentioning

confidence: 99%

See 2 more Smart Citations

<p>Cushing’s Disease Caused by a Pituitary Microadenoma Coexistent with a Meningioma: A Case Report and Literature Review</p>

Wang¹,

Sun²,

Jiang³

2020

IJGM

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“…[ 1 - 3 , 5 , 6 , 8 , 9 , 13 - 15 ] However, a thorough review of the literature reveals that in most of the cases described in these reports/series, there is a preponderance of sellar/parasellar meningiomas. [ 2 , 5 , 8 ] There are only a few cases of coexisting PA and meningioma, in which the meningioma was located far away from the adenoma. [ 3 , 6 , 9 , 13 - 15 ] Table 1 summarizes these cases.…”

mentioning

confidence: 99%

Coexistent pituitary adenoma and frontal convexity meningioma with frontal sinus invasion: A rare association

Gosal

Shukla

Praneeth

et al. 2020

Surgical Neurology International

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The coexistence of pituitary adenoma (PA) and meningioma in the same patient is rare, after excluding radiotherapy-induced meningiomas. Most of the literature on their coexistence describes meningiomas located in the close vicinity to PA, that is, in the sellar/parasellar region. We describe a case of a 65-year-old lady with a nonfunctioning PA and an associated frontal convexity meningioma with frontal sinus invasion. The imaging was nonspecific for the meningioma, and its association with concomitant PA has not been reported before.

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Multiple tumorous lesions of the pituitary gland

et al. 2022

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Purpose/Objective Multiple tumorous lesions in one pituitary gland are rare and mostly described in case reports. Their incidences and combinations are defined in larger collectives. Therefore, we analyzed our large collection for double tumors and combinations of tumors, cysts, and inflammation. Methods The German Registry of Pituitary Tumors, including cases from 1990 to 2018, served as the database. Our collection comprises a total of 16,283 cases up until the end of 2018. Of these cases, 12,673 originated from surgical and 3,610 from autopsy material. All specimens were fixed in formalin and embedded in paraffin. The sections were stained with hematoxylin–eosin and PAS. Monoclonal (prolactin, TSH, FSH, LH, and α subunit) or polyclonal (GH and ACTH) antibodies were used to detect pituitary hormones in the lesions. Since 2017, antibodies against the transcription factors Pit-1, T-Pit, and SF-1 have been used in difficult cases. The criteria of the 2017 WHO classification have been basic principles for classification since 2018 (Osamura et al. 2017). For differentiation of other sellar tumors, such as meningiomas, chordomas, or metastases, the use of additional antibodies was necessary. For these cases, it was possible to use a broad antibody spectrum. Autopsy pituitaries were generally studied by H&E and PAS sections. If any lesions were demonstrated in these specimens, additional immunostaining was performed. Results Multiple tumorous lesions with more than one pituitary neuroendocrine tumor (PitNET) respectively adenoma make up 1.4% (232 cases) in our collection. Within the selected cases, synchronous multiple pituitary neuroendocrine tumors (PitNETs) account for 17.3%, PANCH cases (pituitary adenoma with neuronal choristoma) for 14.7%, PitNETs and posterior lobe tumors for 2.2%, PitNETs and metastases for 5.2%, PitNETs and mesenchymal tumors for 2.6%, PitNETs and cysts for 52.2%, and PitNETs and primary inflammation for 6.0%. The mean patient age was 53.8 years, with a standard deviation of 18.5 years. A total of 55.3% of the patients were female and 44.7% were male. From 1990 to 2018, there was a continuous increase in the number of multiple tumorous lesions. Conclusion From our studies, we conclude that considering possible tumorous double lesions during surgeries and in preoperative X-ray analyses is recommended.

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Unexpected concomitant pituitary adenoma and suprasellar meningioma: a case report and review of the literature

Cited by 12 publications

References 40 publications

<p>Cushing’s Disease Caused by a Pituitary Microadenoma Coexistent with a Meningioma: A Case Report and Literature Review</p>

<p>Cushing’s Disease Caused by a Pituitary Microadenoma Coexistent with a Meningioma: A Case Report and Literature Review</p>

Coexistent pituitary adenoma and frontal convexity meningioma with frontal sinus invasion: A rare association

Multiple tumorous lesions of the pituitary gland

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