Unexpected Cocaine Intoxication in a Fourteen Month Old Child Following Topical Administration

Schou, Henning; Krogh, B; Knudsen, Flemming

doi:10.3109/15563658708992644

Cited by 10 publications

(3 citation statements)

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“…The effects of systemically absorbed cocaine are well documented and include tachycardia, convulsions, loss of consciousness and respiratory depression, both in adults and children. [1][2][3][4] Cocaine can also potentiate the effects of exogenously administered adrenaline on the heart resulting in arrhythmias, hypertension and death. 1,5,6 The maximum safe dose of cocaine in clinical practice is 200.mg, yet toxic effects have been reported from doses as low as 20.mg suggesting that toxicity from cocaine does not necessarily follow a linear scale of dose to response.…”

Section: Discussionmentioning

confidence: 99%

Current practices of cocaine administration by UK otorhinolaryngologists

Uppal

Shehab

et al. 2003

J. Laryngol. Otol.

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The aim of this study was to determine which anaesthetic and vasoconstrictor preparations UK Otorhinolaryngologists use for rhinological surgery, with particular reference to cocaine and adrenaline. The incidence and types of adverse reactions to cocaine were also recorded. A postal survey of all BAO-HNS consultant members was performed. Of the 360 consultant surgeons included in the survey, the majority still use peri-operative cocaine on a regular basis, 66 per cent use cocaine and adrenaline together and more than 40 per cent use cocaine in paediatric patients. Sixteen per cent of respondents did not use cocaine. Only 11 per cent of surgeons had experienced cocaine toxicity in their patients, with only one recorded case of mortality. Most surgeons in the UK use cocaine because of the superior operative field it provides and because they consider it to be safe even with adrenaline. The actual incidence of adverse reactions to cocaine is low, with serious complications being less common than the risks from general anaesthesia. Cocaine remains a valuable agent in the armamentarium of the rhinologist.

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Section: Discussionmentioning

confidence: 99%

Current practices of cocaine administration by UK otorhinolaryngologists

Uppal

Shehab

et al. 2003

J. Laryngol. Otol.

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“…1 However, this is also a global problem. 2,3 Death or severe poisonings of children caused by accidental intake or intentional administration were reported for heroin, 4,5 methadone, [6][7][8][9][10][11][12][13][14][15] cocaine, [16][17][18][19][20] and ecstasy. 21 Between them, the number of death cases with methadone is particularly high and has caught attention since the introduction of this drug as an opioid analgesic in 1947 and for opiate withdrawal therapy in the 1960s.…”

Section: Introductionmentioning

confidence: 99%

Methadone and Illegal Drugs in Hair From Children With Parents in Maintenance Treatment or Suspected for Drug Abuse in a German Community

Pragst

Broecker

Hastedt

et al. 2013

Therapeutic Drug Monitoring

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“…Schou et al reported an unexpected cocaine intoxication following the topical administration of 30 mg cocaine in a 14-month-old infant who underwent bronchoscopy for a foreign body. 86 Passive freebase cocaine inhalation by infants and toddlers exposed to cocaine freebase or crack smoke has resulted in severe disability and death. Bateman and Heagarty reported severe neurological abnormalities in six young children who were exposed to crack.…”

Section: Respiratory Difficulties In Neonates and Infantsmentioning

confidence: 99%

Respiratory Complications of Cocaine Abuse

Perper

Thiel

1992

Recent Developments in Alcoholism

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Abstract. Upper respiratory and pulmonary complications of cocaine addiction have been increasingly reported in recent years, with most of the patients being intravenous addicts, users of freebase, or smokers of "crack."The toxicity of cocaine is complex and is exerted via multiple central and peripheral pathways. Recurrent snorting of cocaine may result in ischemia, necrosis, and infections of the nasal mucosa, sinuses, and adjacent structures.Pulmonary complications of cocaine toxicity include pulmonary edema, pulmonary hemorrhages, pulmonary barotrauma, foreign body granulomas, cocaine related pulmonary infection, obliterative bronchiolitis, asthma, and persistent gas-exchange abnormalities.Respiratory manifestations are nonspecific and include shortness of breath, cough, wheezing, hemoptysis, and chest pains. Severe respiratory difficulties have been reported in neonates of abusing mothers.In the absence of a cocaine-abuse history, it may be difficult to recognize the etiological role of cocaine, especially in the absence of needle tracks pointing to previous intravenous drug abuse and! or negative toxicology.

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Unexpected Cocaine Intoxication in a Fourteen Month Old Child Following Topical Administration

Abstract: We report an unexpected cocaine intoxication following the topical administration of 30 mg cocaine in a fourteen month old boy undergoing bronchoscopy for removal of a foreign body. Possible explanations are discussed. The child recovered completely.

Cited by 10 publications

References 1 publication

Current practices of cocaine administration by UK otorhinolaryngologists

Current practices of cocaine administration by UK otorhinolaryngologists

Methadone and Illegal Drugs in Hair From Children With Parents in Maintenance Treatment or Suspected for Drug Abuse in a German Community

Respiratory Complications of Cocaine Abuse

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