Unexpected benefits of arthroplasty

Haddad, Fares S.

doi:10.1302/0301-620x.104b3.bjj-2022-0115

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Arthroplasty is a well-established and effective surgical procedure for the treatment of various end-stage joint diseases, resulting in favorable clinical outcomes [1]. The primary objectives of arthroplasty are to alleviate pain, improve patients' quality of life, and restore joint function [2,3]. However, despite advancements in surgical techniques, some patients remain dissatis ed with the surgical outcome due to unresolved postoperative complications, including periprosthetic fracture, periprosthetic infection, prosthetic loosening, and joint dislocation [4].…”

Section: Introductionmentioning

confidence: 99%

The Causal Relationship Between Ankylosing Spondylitis and mechanical complications of prosthesis after arthroplasty: A Two-Sample Mendelian Randomization Study

Duan

Zhao

Zhang

et al. 2023

Preprint

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Background： The relationship between ankylosing spondylitis (AS) and mechanical complications of prosthesis after arthroplasty has garnered increasing attention in the medical community. However, the causal relationship between them remains unclear. We conducted a novel study utilizing a two-sample Mendelian randomization analysis to investigate the relationship between these two diseases. Methods: In this study, we obtained single-nucleotide polymorphisms (SNPs) strongly associated with AS and mechanical complications of prosthesis from summary data from genome-wide association studies (GWAS). AS was used as exposure and SNPs as instrumental variables (IVs). The causality was assessed using inverse variance weighted method, and the results were presented as odds ratios (OR). In addition, we conducted heterogeneity tests, horizontal pleiotropy tests, and sensitivity analysis to investigate the potential existence of any bias that may impact the causal relationship. Results: Our results indicate that AS has a causal effect that promotes mechanical complications of prosthesis, as assessed by the inverse variance weighted (IVW) method (OR= 1.037, 95% CI = 1.011, 1.062; P = 0.00366). Although the results of other methods such as MR Egger, weighted median, simple mode， and weighted mode showed no significant causal relationship between the two diseases (P > 0.05), the IVW results should be considered the primary criterion of causality, indicating that AS is a facilitator of mechanical complications of prosthesis. Heterogeneity tests, horizontal pleiotropy tests, and sensitivity analysis showed that these results are reliable and stable. Conclusion: In a word, the results of this Mendelian randomized study suggest that ankylosing spondylitis is associated with an increased risk of mechanical complications of prosthesis after arthroplasty. Therefore, it is recommended that AS patients undergo careful assessment and monitoring during the surgical process to minimize the risk of such complications.

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Section: Introductionmentioning

confidence: 99%