Unesterified Fatty Acids and the Binding of Tryptophan in Human Plasma

Curzon, G.; Friedel, J.; Katamaneni, Bharati D.; Greenwood, Monica H.; Lader, M.

doi:10.1042/cs0470415

Cited by 21 publications

(16 citation statements)

References 8 publications

(12 reference statements)

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“…T. Phillipson and E. D. Bird, unpublished work). Central serotoninergic mechanisms are known to be sensitive to alterations in these factors in the rat (Curzon, Friedel, Kantamaneni, Greenwood & Lader, 1974;Fernstrom & Wurtman, 1972; Biggio, Fadda, Fanni, Tagliamonte & Gessa, 1974) and in man (Perez-Cruet, Chase & Murphy, 1974). Therefore serotonin may play a role in the production of the abnormalities in growth hormone secretion described in this paper.…”

Section: Discussionmentioning

confidence: 99%

Plasma Growth Hormone Concentrations in Huntington's Chorea

Phillipson

Bird

1976

Clinical Science

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1. Growth hormone secretion was assessed in nine control subjects and nine patients with Huntington's chorea. 2. Early-morning fasting plasma samples from patients with Huntington's chorea contained abnormally high concentrations of growth hormone. 3. The suppression of growth hormone after oral glucose in choreic patients, unlike the control subjects, occurred at irregular intervals after the glucose was given and was followed, again at irregular intervals, by an exaggerated rebound phase. 4. The response to intravenous insulin was not markedly abnormal in choreic patients. However, there was a significant increase in the rate of rise of growth hormone concentration in the first half and hour after the insulin injection when compared with control subjects.

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Section: Discussionmentioning

confidence: 99%

Plasma Growth Hormone Concentrations in Huntington's Chorea

Phillipson

Bird

1976

Clinical Science

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“…Recently, it has been shown that increasing the amount of plasma tryptophan which is unbound i.e., 'free' also increases brain tryptophan (Knott & Curzon, 1972). Administration of tryptophan produces a rise in both total and free tryptophan concentration but as the binding sitesapproximately one per albumin molecule (Curzon, Friedel, Kantameneni, Greenwood & Lader, 1974)-approach saturation the concentration of free tryptophan rises more rapidly and to a relatively greater extent than does total tryptophan.…”

Section: Introductionmentioning

confidence: 99%

The acute effects of oral (‐)‐tryptophan in human subjects.

Greenwood¹,

Lader²,

Kantameneni³

et al. 1975

Brit J Clinical Pharma

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1 The psychotropic effects of a single oral dose of (‐)‐tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self‐ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.

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“…As to the decrease of albuminbound serum Trp concentration and the increase of free serum Trp concentration under nephrotic conditions, these changes seem to be due to not only the decrease of serum albumin levels but also the increase of serum NEFA levels. It has been shown in vitro and in vivo that long-chain fatty acids weaken the binding of Trp to albumin (Curzon et al, 1973;Curzon et al, 1974;Brodersen et al, 1989;Sasaki et al, 1993b). In the PAN-treated rats, serum NEFA levels changed in parallel with the changes of albumin-bound serum Trp and free serum Trp levels.…”

Section: Discussionmentioning

confidence: 90%

“…It is known that besides Trp, endogenous substances such as long-chain fatty acids, unconjugated bilirubin, and bile acids bind to albumin (Peter, 1985). In addition, it has been demonstrated in vitro and in vivo that long-chain fatty acids weaken the binding of Trp to albumin (Curzon et al, 1973;Curzon et al, 1974;Brodersen et al, 1989;Sasaki et al, 1993b). Pirazzoli et al (1983) have reported that in children with nephrotic syndrome, a decrease in total plasma Trp levels occurs with an increase in free plasma Trp levels and that there are a positive correlation between albumin and albumin-bound Trp concentrations and a negative correlation between albumin and free Trp concentrations in the plasma.…”

Section: Introductionmentioning

confidence: 99%

Change of serum L-tryptophan levels following the development and recovery of acute puromycin aminonucleoside nephrosis in rats

et al. 1997

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Summary.It is known that total L-tryptophan (Trp) levels decrease with a decrease in albumin-bound Trp levels and an increase in free Trp levels in the plasma or serum of nephrotic children. We, therefore, examined the change of serum Trp levels following the development and recovery of acute nephrosis in 6-week-old male Wistar rats injected once with puromycin aminonucleoside (100mg/kg body weight) and checked the levels of 16 amino acids including Trp in the serum and the levels of Trp in the liver, kidney, and urine under nephrotic conditions. In this study, the development and recovery of nephrosis were checked by the changes of levels of urinary protein and serum protein and albumin. Total serum Trp and albumin-bound serum Trp levels decreased with the development of nephrosis and these decreased levels returned to the normal level with its recovery. In contrast, free serum Trp levels increased with the development of nephrosis and this increased level returned to the normal level with its recovery. In the serum of nephrotic rats, the decrease of albumin-bound Trp levels and the increase of free Trp levels were well consistent with a decrease in albumin levels and an increase in the level of non-esterified fatty acids which are known to weaken the binding of Trp to albumin and among 16 amino acids studied, only Trp showed a significant change in its levels. Trp levels increased in the liver and kidney but not in the urine under nephrotic conditions. These results indicate that the change of serum Trp levels should be c!osely related to the condition of nephrosis and that although serum Trp is lost under nephrotic conditions, the lost serum Trp is accumulated in the liver and kidney.

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Unesterified Fatty Acids and the Binding of Tryptophan in Human Plasma

Cited by 21 publications

References 8 publications

Plasma Growth Hormone Concentrations in Huntington's Chorea

Plasma Growth Hormone Concentrations in Huntington's Chorea

The acute effects of oral (‐)‐tryptophan in human subjects.

Change of serum L-tryptophan levels following the development and recovery of acute puromycin aminonucleoside nephrosis in rats

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