Unerwünschte Arzneimittelwirkungen

Abstract

Adverse drug reactions (ADR) occur in about 5% of all pharmacologically treated patients. Between 2% and 20% of all hospital admissions are caused by ADR, and approximately 10% of all hospitalized patients experience ADR during their hospital stay. Several thousand patients die due to ADR in Germany each year. ADR-associated drugs come predominantly from the class of non-steroidal antiinflammatory drugs, anticoagulants, acetylsalicylic acid and cardiovascular drugs. Most ADR cases present as gastrointestinal bleeding and adverse cardiovascular effects. Apart from this, one or more drugs are withdrawn from the market each year because of unwanted but mostly rare side effects. In recent years the most prominent cases were rofecoxib, cisapride and cerivastatin. Physicians in Germany are obliged to report ADR. A substantial proportion of ADR, however, is not reported because it is deemed to be either too well known or the association between the drug and the adverse effect is too doubtful. In some cases, histopathological findings are needed to determine the diagnosis of ADR. Accordingly, physicians should inform the pathologist whether an ADR is suspected and which drugs may be responsible.

Targeted Metabolomics for Biomarker Discovery

“…For example, ADR occurs in approximately 5 % of all treated patients; it has been estimated that 2-20 % of all hospital admissions are due to ADR, and about 10 % of all hospitalized patients experience ADR during their hospital stay. [182] Among these, metabolic disorders represent 10.2 % of ADR related to cardiovascular drug therapy in Germany [183] and about 12 % in cardiology hospitals in France. [184] Interestingly, human embryonic stem cells capable of differentiating into a variety of cell types, may, as claimed by Stemina (http:// www.stemina.com/), offer a promising alternative for toxicity screening, for example, cardiomyocyte progenitors could be used in predictive toxicology.…”

“Targeted Metabolomics” in der Biomarkerforschung

“…Toxizität und Nebenwirkungen sind aber auch Probleme für zugelassene Arzneimittel. Schätzungsweise 2–20 % aller Klinikeinweisungen gehen auf unerwünschte Nebenwirkungen zurück, diese treten bei etwa 10 % aller hospitalisierten Patienten auf 182. Darunter sind in Deutschland 10.2 % unerwünschte Wirkungen bei der Arzneimitteltherapie kardiovaskulärer Erkrankungen183 und ca.…”

Lokale allergische Reaktion nach subkutaner Applikation von Procain bei einem Patienten mit Schulterschmerzen – Fallbericht

“…Unerwünschte Reaktionen auf Arzneimittel treten schätzungsweise bei ca. 5 % aller medikamentösen Behandlungen auf [1]. Da nicht alle unerwünschten Wirkungen erkannt oder ärztlich behandelt werden, ist von einer hohen Dunkelziffer auszugehen [2].…”