Unequal expression of allelic allotypic specificities in circulating immunoglobulins, experimentally-elicited antibodies, and receptor-carrying cells

Chou, C.‐T.; Cinader, B.; Dubiski, S.

doi:10.1016/0008-8749(74)90029-x

Cited by 23 publications

(6 citation statements)

References 9 publications

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“…Our results also suggest that the quantitative imbalances in allotype expression by mature B cells and plasma cells in heterozygotes (Chou et al 1974) may be due to immunoregulatory mechanisms rather than preferential gene activation.…”

Section: In Vivo Effects Of Anti-allotype Antibodiesmentioning

confidence: 55%

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

Cooper

Kearney

Gathings

et al. 1980

Immunological Reviews

100

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Section: In Vivo Effects Of Anti-allotype Antibodiesmentioning

confidence: 55%

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

Cooper

Kearney

Gathings

et al. 1980

Immunological Reviews

100

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“…The number of lymphocytes stimulated to transform is also deereased in suppressed rabbits (Sell 1968b, Marcuson & Roitt 1969, Harrison et al 1974. 5) There is a pecking order of allotypie expression (b4 > b6 > b5 > b9) in the serum immunoglobulin concentrations (Rieder & Oudin 1963, Lark et al 1965, Catty et al 1969, Dubiski et al 1970 and tissue plasma cells (Chou 1972(Chou , 1974 of heterozygous rabbits. In general, this same peck-STEWART SELL ing order exists for the magnitude of the blast transformation response , Sell 1968a.…”

Section: Similarities Of Allotype Suppression and Allotype Transformamentioning

confidence: 99%

A Speculative Comparison of Allotypic Suppression and Allotypic Blast Transformation: Control of Expression of T and B Cell Immunoglobulin Allotypic Markers by a B Cell Product

Sell

1975

Immunological Reviews

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“…The following "pecking order" is observed: b4 > bS > b6 > b9 with a b4/b9 allelic ratio of 80:20 (3)(4)(5)(6). These alleles are characterized by a high level of divergence at the protein level (ranging from 22 to 33% of divergence).…”

mentioning

confidence: 99%

Evolution of the immunoglobulin kappa light chain locus in the rabbit: evidence for differential gene conversion events.

Akimenko¹,

Mariamé²,

Rougeon³

1986

Proc. Natl. Acad. Sci. U.S.A.

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The rabbit Kc light chain gene family is characterized by the presence of two constant region (CQ) genes; the Cd gene encodes the constant region of the principal rabbit immunoglobulin light chain, the CK2 gene being not or very poorly expressed in domestic rabbits. There exist four major KI alleles (b4, b5, b6, and b9), which are unequally expressed in heterozygous rabbits at the K) locus. Here, we compare the nucleotide sequences of the joining (J) clusters of the K light chain gene (JK) linked to the b4K2 locus and to the b and b9 alleles at the K) locus. As for CK genes, there is evidence for intergenic conversion between the Jud and JK,2 clusters as well as maximum divergence in the expressedJ segments. The b9Jd cluster differs from its b4 counterpart in that two out of the five JK segments (Ji and J2) are expressed instead of only one. This implies that preferential expression of the b4 allele as compared to the b9 allele is not only correlated to the number of available Je pieces. The b9 J2 segment is functional in spite of the presence of a termination codon immediately upstream of its coding region. Two major structural differences were observed between the J-C intron sequences of the b9 and b4 alleles; namely a 160-base-pair deletion of an A+T-rich sequence in b9 (which also occurs in the K2 locus) and a 10-base-pair deletion plus some substitutions in the region corresponding to the mouse K intron activating element. These differences could underlie the lower transcriptional rate of the b9 allele.The rabbit immunoglobulin K light chain gene family constitutes an interesting model for the study of complex allele evolution and of the cis elements that control gene expression. In contrast to the situation in humans and mice, in domestic rabbits two K chain loci, K) and K2, encode the K chain bearing the nominal b allotype of the rabbit and the bas chain expressed in wild rabbits and in rabbits of the Basilea strain, respectively (1, 2).In mature B cells of rabbits heterozygous for the K) locus, the two alleles are unequally expressed. The following "pecking order" is observed: b4 > bS > b6 > b9 with a b4/b9 allelic ratio of 80:20 (3-6). These alleles are characterized by a high level of divergence at the protein level (ranging from 22 to 33% of divergence). Structural analysis of the corresponding genes has suggested that most of the differences have been generated by gene conversion (7). Another remarkable feature of the K) locus is that, at least in the case of the b4 allele, only one out of the five joining (J) segments of the K light chain (QJ) is functional (8, 9). The decrease in diversity that could result from this limited combinatorial potential is compensated for by an increased junctional variation during the V-J (V, variable) recombination because of nucleotide deletions in the JK segments and length heterogeneity of the VK germ-line segments (10). From nucleotide sequencing data of the human, mouse, and rabbit genes, a highly conserved region has been identified within the J-CK intro...

show abstract

Unequal expression of allelic allotypic specificities in circulating immunoglobulins, experimentally-elicited antibodies, and receptor-carrying cells

Cited by 23 publications

References 9 publications

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

A Speculative Comparison of Allotypic Suppression and Allotypic Blast Transformation: Control of Expression of T and B Cell Immunoglobulin Allotypic Markers by a B Cell Product

Evolution of the immunoglobulin kappa light chain locus in the rabbit: evidence for differential gene conversion events.

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