Unearthing Bulgakov's trace proteome from the Master i Margarita manuscript

Zilberstein, Gleb; Maor, Uriel; Baskin, E.; D’Amato, Alfonsina; Righetti, Pier Giorgio

doi:10.1016/j.jprot.2016.10.019

Cited by 33 publications

(25 citation statements)

References 22 publications

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“…Numerous groups have successfully analysed host DNA as well as the microbiome of various historical documents using NGS [7,38,46]. There has also been differing non-invasive methods developed to recover proteins from both paper and parchment documents [49][50][51] revealing evidence of disease and substance use, which can open exciting new avenues of research.…”

Section: Discussionmentioning

confidence: 99%

So you want to do biocodicology? A field guide to the biological analysis of parchment

et al. 2019

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Biocodicology, the study of the biological information stored in manuscripts, offers the possibility of interrogating manuscripts in novel ways. Exploring the biological data associated to parchment documents will add a deeper level of understanding and interpretation to these invaluable objects, revealing information about book production, livestock economies, handling, conservation and the historic use of the object. As biotechnological methods continue to improve we hope that biocodicology will become a highly relevant discipline in manuscript studies, contributing an additional perspective to the current scholarship. We hope that this review will act as a catalyst enabling further interactions between the heritage science community, manuscript scholars, curators and conservators.

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Section: Discussionmentioning

confidence: 99%

So you want to do biocodicology? A field guide to the biological analysis of parchment

et al. 2019

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“…The scientific approach to discovering these interesting aspects was based on a cation exchange separation followed by GC-MS. In a following study, three proteinaceous biomarkers of a nephrotic syndrome were also found among the detected proteins, suggesting that probably the kidney intense pain related to this syndrome rendered necessary this drug treatment in the last years of Bulgakov's life (Zilberstein et al 2017). However, the majority of literature articles concern the detection of binders used both in wall and paper paintings.…”

Section: Identification Of Proteins In Artworkmentioning

confidence: 93%

Back to the past: deciphering cultural heritage secrets by protein identification

Giuffrida

Mazzoli

Pessione

2018

Appl Microbiol Biotechnol

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The present review article reports the most innovative methods to detect proteins in historical and archeological samples as well as to characterize proteins used as binders in artworks. Difficulties to ascribe proteins to a certain animal species are often due to post-translational modifications originated by chemical or microbial deterioration during aging. Combining different techniques such as peptide mass fingerprinting and tandem mass spectrometry can solve some of these problems and also allow discrimination between taxonomically related species like sheep and goat. The most studied proteins in bones and textile samples are osteocalcin, collagen and keratin, whereas egg yolk and white proteins, casein and collagen are the most relevant for binders used in old paintings. With the suitable approaches (immune-based methods, DOT-blot, etc…) it is also possible to obtain in situ characterization or analyze the samples directly in the museum laboratories, with the advantage of avoiding artwork damage and expensive external commitments. Recent cutting-edge strategies allowed detection of proteinaceous infection markers that, for instance, were used to establish the cause of death of old Inca mummies and also proved the presence of Yersinia pestis in old documents dating from the period in 17th century in which the plague ravaged Europe.

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“…In this way the multi-layered and multuspheric philosophical space of Bulgakov's mysterious novel is born. And space and characters in these constructs seem to mirror and 'triple' each other [7], [8], [9], [10].…”

Section: Mythological Worlds Of the Novel By Mikhail Bulgakov 'The Mamentioning

confidence: 99%

Features of the Author�s Worldview in the Novel by Mikhail Bulgakov �the Master and Margarita�

Karlova¹

2017

4th International Multidisciplinary Scientific Conference on Social Sciences and Arts SGEM2017, SCIENCE and ARTS

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The article analyzes the mythological systems, that had a significant impact on the outlook of Mikhail Bulgakov as the author of the great novel 'The Master and Margarita', the iconic literary work in Russia of XX-of XXI centuries. The article criticizes the tradition of literary studies, where the philosophical context of the novel 'The Master and Margarita' is interpreted exclusively in the context of Russian philosophical tradition. The article identifies three semantic constructs of the novel, reveals their basic content, their mutual influence. Based on the analysis of mythological storylines, the content of the philosophical worldview of Mikhail Bulgakov is constructed.

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Unearthing Bulgakov's trace proteome from the Master i Margarita manuscript

Cited by 33 publications

References 22 publications

So you want to do biocodicology? A field guide to the biological analysis of parchment

So you want to do biocodicology? A field guide to the biological analysis of parchment

Back to the past: deciphering cultural heritage secrets by protein identification

Features of the Author�s Worldview in the Novel by Mikhail Bulgakov �the Master and Margarita�

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