Une nouvelle méthode simple pour explorer l’action «tranquillisante»: le test de la cheminée

Boissier, J.R.; Tardy, J.; Diverres, J.-C.

doi:10.1159/000134913

Cited by 260 publications

(117 citation statements)

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“…Then the analysis of the recorded data was achieved. The ''chimney'' test 33 is another in vivo test used to evaluate the mouse motor coordination impairments. It is based on the time that the rodent needs to traverse a tube of glass or clear acrylic 20 cm long in a span of 10 s. In this assay, the degree of muscular relaxation in mice is evaluated.…”

Section: Methodsmentioning

confidence: 99%

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Díaz

Camí

Liu‐González

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.

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Section: Methodsmentioning

confidence: 99%

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Díaz

Camí

Liu‐González

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The mice receiving RTG and TPM in high doses displayed ataxia and impairment of motor performance, which were quantified with the chimney test [17]. In this test, the mice had to climb backwards up a transparent plastic tube (3 cm inner diameter, 30 cm length) within 1 min., as described in more detail elsewhere [11,12].…”

Section: Animalsmentioning

confidence: 99%

“…The chimney test is considered to be a model assessing acute adverse (neurotoxic) effects in experimental animals with respect to the impairment of motor coordination [17]. To exclude any pharmacokinetic interactions, total brain concentrations of both, RTG and TPM were determined.…”

Section: Introductionmentioning

confidence: 99%

Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test – an isobolographic analysis

Zagaja¹,

Miziak²,

Kondrat-Wróbel³

et al. 2017

J Pre Clin Clin Res.

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Zagaja M, Miziak B, Kondrat-Wróbel MW, Andres-Mach M, Wróblewska-Łuczka P, Adamczuk P, Chmura R, Czuczwar SJ, Łuszczki JJ. Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test -an isobolographic analysis. J Pre-Clin Clin Res. 2017; 11(1): 61-65. doi: 10.26444/jpccr/74557 Abstract Introduction and objectives. Nowadays, one of the treatment options for patients with refractory epilepsy is polytherapy with two or more antiepileptic drugs (AEDs). Retigabine (RTG) is a novel third-generation AED with unique molecular mechanisms of action that has recently been approved as an add-on drug for the treatment of tonic-clonic seizures. To characterize types of interactions between RTG and topiramate (TPM -a second-generation AED), the maximal electroshock-induced seizure model (MES) and chimney test in mice were used. Materials and method. In the MES model, the anticonvulsant effects of the drugs in terms of suppression of tonic-clonic seizures in male albino Swiss mice were assessed. In the chimney test, the acute neurotoxic effects of the drugs with respect to impairment of motor coordination were determined. Type I isobolographic analysis for the combination of RTG and TPM was applied to assess the anticonvulsant and neurotoxic effects in both the MES and chimney tests. Total brain concentrations of RTG and TPM were measured to exclude any pharmacokinetic interaction between drugs. Results. The type I isobolographic analysis of interaction revealed that the combination of RTG with TPM produced additive interaction in the MES test and additivity, with a slight tendency towards antagonism in terms of acute neurotoxic effects in the chimney test. Neither RTG nor TPM mutually affected total brain concentrations in the experimental animals. Conclusions. The isobolographically analyzed combination of RTG with TPM is favourable and may be recommended to some patients with refractory epilepsy.

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“…The acute neurotoxicity of the selected compounds was assessed according to a method described by Boissier et al [35]. In this test, the animals had to climb backwards up the tube.…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Synthesis and Evaluation of 3‐[(2,4‐Dioxo‐1,3,8‐triazaspiro[4.6]undec‐3‐yl)methyl]benzonitrile Derivatives as Potential Anticonvulsants

Madaiah

Prashanth

Revanasiddappa

et al. 2013

Archiv der Pharmazie

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New 3- [(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Compounds 11, 18, 31, and 32 showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, that is, a lipophilic domain, a hydrophobic center, and a twoelectron donor.

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Une nouvelle méthode simple pour explorer l’action «tranquillisante»: le test de la cheminée

Cited by 260 publications

References 0 publications

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test – an isobolographic analysis

Synthesis and Evaluation of 3‐[(2,4‐Dioxo‐1,3,8‐triazaspiro[4.6]undec‐3‐yl)methyl]benzonitrile Derivatives as Potential Anticonvulsants

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