Une localisation exceptionnelle d’un hémangiome intraosseux

Ghedira, A.; Daghfous, M.; Baccari, S.; Abid, Leïla; Ounaies, Mouna; Jaafoura, Mohamed Habib; Tarhouni, L.

doi:10.1016/j.main.2010.09.017

Cited by 2 publications

(1 citation statement)

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“…The incidence of GC varies from one geographic region to another, suggesting that genetic and environmental factors including Helicobacter pylori infection are considered to contribute to gastric carcinogenesis [2,3]. In southern Tunisia, the annual incidence of GC varies from 2.6 to 4.8/100 000 persons [4]. In the few past years, many reports have explored the association between Epstein-Barr Virus (EBV) infection and GC [5-9].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia

BenAyed-Guerfali

Ayadi

Miladi-Abdennadher

et al. 2011

Virol J

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BackgroudEBV-associated Gastric Carcinoma (EBVaGC) has a distinct clinical features and its prevalence is variable worldwide.ResultsTo determine the prevalence of EBVaGC in Tunisia, EBV-encoded small RNA (EBER) expression was assessed in 81 gastric carcinoma (GC) specimens. The nuclear EBER expression was detected in 12 out of 81 GC cases (14.81%) and concordance between the score range of EBER staining and the number of EBV DNA copies as estimate by QPCR is observed. On the other hand, we found that EBVaGC strongly correlated with age at diagnosis, and weakly with tumor differentiation and venous invasion.Furthermore, the EBVaGC specimens were subjected to determine the EBV DNA polymorphisms. Our results show a unique genetic profile of the EBV strains regarding the A and D types, the F prototype, the retention of XhoI restriction site and the 30 bp del-LMP1 variant. According to our previous studies on nasopharyngeal carcinoma (NPC), we suggested that EBV strains associated to GC and NPC shared some similarities in Tunisian patients.ConclusionThe prevalence of EBVaGC is of 14.81% in the southern Tunisia and that common EBV strain are associated with both NPC and GC which are likely to differ from Asian strains. Our findings support therefore a certain geographical distribution of EBV strains which is not restricted to EBV-associated malignancies.

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Section: Introductionmentioning

confidence: 99%