Une interférence analytique peut en cacher une autre : l’exemple de l’urapidil, du dépistage de MDMA et de l’identification d’un stimulant de synthèse, la 2-MeOPP

2‐MeOPP positive hair result in case of urapidil treatment

“…Data from the literature showed that its metabolism in humans leads to the production of two hydroxylated and three demethylated metabolites 4 . Furthermore, 2‐MeOPP has been suggested to be an urapidil metabolite 5,6 . In the same way, 1‐(4‐hydroxyphenyl)piperazine (4‐HO‐PP), a major metabolite of 1‐(4‐methoxyphenyl)piperazine (4‐MeOPP), has been reported as being a metabolite of drugs such as dropropizine and oxypertine 7 …”

“…4 Furthermore, 2-MeOPP has been suggested to be an urapidil metabolite. 5,6 In the same way, 1-(4-hydroxyphenyl)piperazine (4-HO-PP), a major metabolite of 1-(4-methoxyphenyl)piperazine (4-MeOPP), has been reported as being a metabolite of drugs such as dropropizine and oxypertine. 7 In this context, we aim to report positive hair results for 2-MeOPP in two cases of urapidil treated patients (with retrospective identification in blood and urine samples in one case) together with an in vitro urapidil metabolism study using human liver microsomes (HLMs) and liquid chromatography with high-resolution mass spectrometry detection (LC-HRMS).…”