Une couleur inhabituelle

Campagne, J.; Kurt, S.; Moulinet, T.; Mohamed, Suziyani; Deibener-Kaminsky, J.; Jaussaud, R.

doi:10.1016/j.revmed.2020.05.012

Cited by 1 publication

(1 citation statement)

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“…The purple urine bag phenomenon was first described by Barlow and Dickson in 1978, who described the rare mechanism of purple color formation in urine bags in children with spina bifida in pediatric wards. The investigation elucidated the bacterial decomposition of dietary amino acid tryptophan in the gut lumen, producing indoxyl sulfate, which is consequently excreted in the urine, then oxidized to insoluble indigo upon contact with the air in a collecting bag [ 8 , 9 ]. A similar clinical manifestation in infants, known as “blue diaper syndrome” (Drummond syndrome), is also a consequence of abnormal tryptophan metabolism but is, however, genetically caused.…”

Section: Discussionmentioning

confidence: 99%

Purple Urine Bag Syndrome in a Home-Dwelling Elderly Female with Lumbar Compression Fracture: A Case Report

et al. 2023

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Purple urine bag syndrome (PUBS) is an uncommon, but usually benign, underrecognized clinical condition with the distressing presentation of purple, blue or reddish discoloration of a patient’s catheter bag and tubing in the setting of catheter-associated urinary tract infections (UTIs). PUBS is the result of the complex metabolic pathway of the dietary essential amino acid tryptophan. Its urinary metabolite, indoxyl sulfate, is converted into red and blue byproducts (indirubin and indigo) in the presence of the bacterial enzymes indoxyl sulfatase and phosphatase. The typical predisposing factors are numerous and include the following: female gender, advanced age, long-term catheterization and immobilization, constipation, institutionalization, dementia, increased dietary intake of tryptophan, chronic kidney disease, alkaline urine, and spinal cord injury (SCI). Here, we present a case of PUBS in a home-dwelling elderly female patient with a history of long-term immobility after a pathological spinal fracture, long-term catheterization, constipation, and malignant disease in remission. Urine culture was positive for Proteus mirabilis. This state can be alarming to both patients and physicians, even if the patient is asymptomatic. Healthcare professionals and caregivers need to be aware of this unusual syndrome as an indicator of bacteriuria in order to initiate proper diagnostics and treatment.

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Section: Discussionmentioning

confidence: 99%