Undulated Multicompartment Cylinders by the Controlled and Directed Stacking of Polymer Micelles with a Compartmentalized Corona

Abstract

Wie ein Bambusstab: Lange gewellte Zylinder mit der Form von Bambusstäben und festgelegten Verzweigungsstellen und Endgruppen (siehe Bild) entstehen durch reversible Stapelung von Blockterpolymer‐Micellen, die aus einem fluorierten Polybutadienkern und einer Korona mit Poly(4‐tert‐butoxystyrol)‐ und Poly(tert‐butylmethacrylat)‐Segmenten bestehen. Die Stapelung der Polymermicellen erfolgte nach dem Wechsel des Lösungsmittels von Dioxan zu Ethanol.

Synthesis of Linear ABC Triblock Copolymers and Their Self‐Assembly in Solution

“…M€ uller and co-workers have demonstrated an elegant way to design multicompartment structures from ABC polymers by dissolving the polymers in a non-solvent for B before slowly exchanging it to a non-solvent for A and B via dialysis. [33][34] [66] Such a preparation procedure results in presumably near-equilibrium structures with A in the core, B forming domains, and C in the corona. Domains can be visualized via transmission electron microscopy (TEM) using selective staining for individual blocks.…”

“…In addition to preferential orientation, polymersomes from ABC polymers enhance the delivery of some drugs. [77][81] [82] ABC polymers with A and C soluble blocks can selfassemble into structures with mixed, patchy, and Janus corona [66][67] [83 -90] with diverse potential applications ranging from materials science to biomedicine. [91] [92] They can also form new types of structures [30] not accessible with conventional AB polymers.…”

Polymeric Janus Particles

“…[59] Similar structures were observed by Fang et al for a poly(tert-butoxystyrene)-block-PB-block-poly(tert-butyl methacrylate) terpolymer in which the PB block was modified by fluoroalkyl groups in a post polymerization process. [60] An altogether different strategy to create Janus particles uses amphiphilic block copolymer brushes. [16,[61][62][63] Such macromolecular architectures self-assemble in block-selective solvents and typically form unimolecular rodlike nanoobjects in which the individual polymer grafts form separated domains.…”

Makromolekulare Chemie 2009

“…Beispielsweise berichteten Müller et al über Mizellen mit kompartimentierter Corona, entstanden durch Selbstorganisation von Terblockcopolymeren. Diese basierten auf Poly(4‐tert‐butoxystyrol)‐b‐Poly(butadien)‐b‐Poly(tert‐butylmethacrylat)en, deren zentraler PB‐Block mit fluorierten Seitengruppen modifiziert wurde 16. In fluorophoben Medien wirkt der zentrale Block als micellarer Kern.…”