Undue Inducement: The Only Objection to Payment?

Vanderwalde, Ari M.

doi:10.1080/15265160500245063

Cited by 7 publications

(3 citation statements)

References 10 publications

(7 reference statements)

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“…The response rate for those who were told they would receive remuneration was 82% and for those who were not told they would receive remuneration, the response rate was 70%. Some ethicists and researchers have expressed concerns about providing monetary incentives for research participation and caution against providing amounts that could have undue influence over participants [Macklin, 1981; McNeill, 1997; VanderWalde, 2005]. However, providing monetary incentives also has been reported to be an act of appreciation that shows investigators' respect for study participants' time and effort [Grady, 2001].…”

Section: Discussionmentioning

confidence: 99%

Qualitative assessment of study materials and communication strategies used in studies that include DNA collection

Jenkins

Reed-Gross

Barfield

et al. 2011

American J of Med Genetics Pt A

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To understand motivations and barriers to participation in studies that include DNA collection, focus group discussions were held with mothers who had participated in a case-control study of birth defects. Recruited mothers had completed an interview and had received a mailed kit containing cytobrushes to collect buccal cells for DNA from herself, her infant, and her infant's father. Six moderator-led focus groups were attended by a total of 38 women residing in Atlanta, Georgia. Focus groups were segmented by DNA collection status (biologics participants or nonparticipants), infant case-control status, infant birthweight, and maternal race and ethnicity. This report assesses maternal attitudes toward study materials and communication strategies. Across groups, respondents expressed concern about how their contact information was obtained. Study materials were described as clear and professional by most women, although some respondents reported confusion about disclosure of individual genetic results. Respondents generally reported that monetary incentives were not a motivation to participate, but increased perceived study legitimacy. Biologics nonparticipants expressed concerns about kit component sterility; government involvement; and DNA sample use, storage, and disposal. Respondents suggested that investigators provide feedback on whether sample collection was performed correctly and provide materials targeted to fathers to help alleviate paternal skepticism. Participation in DNA collection might be improved by strengthening study materials and communication strategies.

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Section: Discussionmentioning

confidence: 99%

Qualitative assessment of study materials and communication strategies used in studies that include DNA collection

Jenkins

Reed-Gross

Barfield

et al. 2011

American J of Med Genetics Pt A

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show abstract

“…The ethical concern about payment to incentivize individuals to take risks in medical research focuses on the potential to be exploitative in that it may create an undue inducement for those who are economically disadvantaged (36,37). Likewise, in the transplant context, the goal of incentivizing individuals to accept the health risks incurred by an organ market raises concerns of exploitation and undue inducement because of power differentials expressed in economic, class and educational attainment between vendors and buyers (38,39).…”

Section: Discussionmentioning

confidence: 99%

How Different Conceptions of Risk Are Used in the Organ Market Debate

Aronsohn

Thistlethwaite

Segev

et al. 2010

American Journal of Transplantation

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The success of kidney and liver transplantation is hindered by a shortage of organs available for transplantation. Although currently illegal in nearly all parts of the world, a living 'donor' or 'vendor' kidney market has been proposed as a means to reduce or even end this shortage. Physician members of the American Society of Transplantation, the American Society of Transplant Surgeons and the American Association for the Study of Liver Disease were surveyed regarding organ markets for both living kidney and living liver transplantation. The survey queried respondents about their attitudes toward directed living donation, nondirected living donation, the potential legalization of living donor organ markets and the reasons for their support or opposition to organ markets. Partial or completed surveys were returned by 346 of 697 eligible respondents (50%). While virtually all supported or strongly supported directed living donation (98% and 95% for kidney and liver lobes, respectively), the vast majority disagreed or strongly disagreed with the legalization of living donor organ markets (80% for kidneys and 90% for liver lobes). Both those who support and those who oppose a legalized living donor organ market rate risk to the donor among the most important factors to justify their position.

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“…The predominant ethical concerns about incentives center around the ways in which they can distort decision making about participation. [31][32][33][34][35][36][37] Offers of large amounts of cash or its equivalents may prompt potential participants to accept risks or burdens that they otherwise would not tolerate, and when researchers pay in such instances they treat research participants as commodities. 38,39 In some cases, a generous offer may inadvertently encourage research participants to lie about their eligibility for the study or to hide adverse effects of an intervention.…”

Section: Incentivesmentioning

confidence: 99%

Incentives and payments in pragmatic clinical trials: Scientific, ethical, and policy considerations

2021

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Pragmatic clinical trials are increasingly used to generate knowledge about real-world clinical interventions. However, they involve some distinctive ethical and regulatory challenges. In this article, we examine a set of issues related to incentives and other payments to patients in pragmatic clinical trials. Although many of the ethical concerns related to incentives and payments in explanatory trials pertain to pragmatic clinical trials, the pragmatic features may introduce additional challenges. These include those related to the risk of incentives and payments undermining the scientific validity and social value of pragmatic clinical trials, the sources of data used in pragmatic clinical trials, and when the pragmatic clinical trials are conducted under waivers of consent. Based on our examination of these matters, we offer some preliminary recommendations regarding incentives and payments in pragmatic clinical trials, recognizing that additional data and experiences are needed to refine them.

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Undue Inducement: The Only Objection to Payment?

Cited by 7 publications

References 10 publications

Qualitative assessment of study materials and communication strategies used in studies that include DNA collection

Qualitative assessment of study materials and communication strategies used in studies that include DNA collection

How Different Conceptions of Risk Are Used in the Organ Market Debate

Incentives and payments in pragmatic clinical trials: Scientific, ethical, and policy considerations

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