Undifferentiated Sex Cord—Stromal Tumor in a Young Adult

Abstract

Undifferentiated sex cord-stromal tumor in post-puberty male is extremely rare. There were only three reported cases in the literature. We reported a 19-year-old patient presented with an asymptomatic right testicular nodule with normal level of serum marker for germ cell tumor. Excisional biopsy and subsequent orchidectomy was preformed and the final pathology supported the diagnosis of undifferentiated sex cord-stromal tumor. He was then put on regular surveillance with no adjuvant therapy given. He remained disease free 18 months after the operation. A summary of the literatures and discussion on the management of this rare tumor was provided.

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

“…Unclassified sex cord-stromal tumors tend to occur over a wider age range than juvenile granulosa cell tumors and include adolescent patients 55,58,59 ; age, therefore, is not as helpful a discriminating feature in their separation from yolk sac tumors. Comments pertinent to serum AFP levels in patients with juvenile granulosa cell tumor versus yolk sac tumor also pertain for unclassified sex cord-stromal tumor versus yolk sac tumor.…”

Unclassified testicular sex cord-stromal tumors in children

“…Follow-up should be close and long term since late recurrences have been described 15 years after diagnosis and to document male sexual development, psychological well-being, quality of life and reproductive health [1,13]. Laboratory tests with tumor markers and imaging studies such as CT, MRI and ultrasound are used.…”