Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis

Kharkhach, Ayoub; Bouhout, Tarik; Serji, Badr; Harroudi, Tijani El

doi:10.1007/s12029-021-00583-4

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Table 2 shows the size in relation to tumor location. At the time of diagnosis, 8 patients (11.6%) presented with locally advanced disease due to the invasion of adjacent organs [ 16 - 21 ], vessels [ 22 ], or lymph nodes [ 23 ]. At the same time, 5 patients (7.2%) exhibited metastatic disease [ 24 - 28 ], primarily involving the liver [ 26 - 28 ], and the lungs [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Surgical resection of the pancreatic neoplasm was the therapeutic treatment in the majority of the patients (61 patients, 88.4%). Bypass surgery was offered to 2 patients, due to extended disease and poor performance status of the patients [ 23 , 24 ], while palliative stent placement was the therapeutic approach in 2 additional patients presenting with concurrent liver metastases [ 26 , 27 ]. Best supportive care was provided to 4 patients, based on their poor performance status [ 29 ], disease burden [ 28 ], and patient preference [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis

Mylonakis,

Driva,

Lykoudis

et al. 2024

Ann Hepatobiliary Pancreat Surg

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Undifferentiated carcinoma with osteoclast-like giant cells (UC−OGCs) of the pancreas is a rare neoplasm that accounts for less than 1% of all pancreatic malignancies. The aim of this study was to review the literature regarding UC−OGC, and to highlight its biological behavior, clinicopathologic characteristics, prognosis, and therapeutic options. A systematic review of the literature in PubMed/Medline and Scopus databases was performed (last search October 31st, 2023) for articles concerning pancreatic UC−OGC in the adult population. Fifty-seven studies met the inclusion criteria, involving 69 patients with a male-to-female ratio of 1.1:1 and a mean age of 62.96. Main symptoms included abdominal pain (33.3%), jaundice (14.5%), weight loss (8.7%), while fourteen patients (20.3%) were asymptomatic. Surgical resection was performed in 88.4% of cases. Survival rates at one, three, and five years were 58%, 44.7%, and 37.3% respectively. Sex, age, size (cut-off of 4 cm), location, and adjuvant treatment did not significantly affect patient survival. UC−OGC of the pancreas is a rare subtype of undifferentiated pancreatic carcinoma with a better prognosis than conventional pancreatic ductal adenocarcinoma or undifferentiated carcinoma without giant cells. The establishment of a dedicated patient registry is imperative to further delineate the optimal treatment for this uncommon clinical entity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis

Mylonakis,

Driva,

Lykoudis

et al. 2024

Ann Hepatobiliary Pancreat Surg

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“…This distinction is not critical for making a diagnosis. Although giant cells may be seen in association with carcinoma, [48][49][50] melanoma, 51 and even some lymphomas, 52 we will focus exclusively on giant cell-rich soft tissue lesions.…”

Section: Benign Neoplastic Giant Cellsmentioning

confidence: 99%

Approach to Fine Needle Aspiration of Giant Cell-rich Tumors of Soft Tissue

Rottmann

Pantanowitz

2022

Advances in Anatomic Pathology

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Giant cells may be found in a wide variety of reactive and neoplastic soft tissue lesions. Because of their distinct histomorphology, they often stand out in procured samples such as fine needle aspirates. The giant cells themselves may be benign or neoplastic. However, the presence, type, and quantity of giant cells are usually not specific and in some cases can even be misleading when making a diagnosis. The aim of this review is to guide the practicing cytopathologist in narrowing their differential diagnosis when encountering one of these challenging giant cell-rich lesions of the soft tissue.

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Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis

Cited by 2 publications

References 32 publications

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis

Approach to Fine Needle Aspiration of Giant Cell-rich Tumors of Soft Tissue

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