Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Njoumi, Noureddine; Elalami, Faricha Hassan; Attolou, Gilles; Saoud, Omar; Elabsi, M.; Echarrab, M.; Elouannani, Mohamed; Errougani, A.; Amraoui, M.; Chkoff, M. R.

doi:10.1007/s12029-013-9572-9

Cited by 11 publications

(9 citation statements)

References 14 publications

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“…Since the growth of tumor is very rapid in a short period of time, UCOGCP often appears as a heterogeneous mass with distinct hemorrhage and necrosis. An inhomogeneous appearance with cystic structures and nonuniform enhancement is the typical radiological finding of UCOGCP (5,6). MRI demonstrated a well-demarcated, heterogeneous cystic tumor with prominent enhancement of the septations and the capsule in our case.…”

Section: Discussionsupporting

confidence: 55%

Huge and recurrent undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

Zhang

Lee

Yoon

et al. 2018

Quant. Imaging Med. Surg.

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Section: Discussionsupporting

confidence: 55%

Huge and recurrent undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

Zhang

Lee

Yoon

et al. 2018

Quant. Imaging Med. Surg.

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“…They are not present in normal tissues other than bones. Nevertheless, similar cells have been found in tumors of pancreas (Abid and Gnanajothy, 2019;Njoumi et al, 2014;Sah et al, 2015;Togawa et al, 2010;Bauditz et al, 2006), liver (Bauditz et al, 2006;Dioscoridi et al, 2015;Ikeda et al, 2003;Kuwano et al, 1984;Rosai, 1990), skin (Goel et al, 2011;Al-Brahim and Salama, 2005;Jiménez-Heffernan et al, 2018;Houang et al, 2015), lung (Nakahashi et al, 1987;Matsukuma et al, 2014;Lindholm et al, 2019;Kong et al, 2015;Dahm, 2017), breast (Stewart and Mutch, 1991;Agnantis and Rosen, 1979;Fadare and Gill, 2009;Ginter et al, 2015;Ohashi et al, 2018), and in many other tumors. Osteoid and bone formation was found in different cancers, such as breast cancer and melanoma (Hoorweg et al, 1997;Dekkers et al, 2019) These tumors can be considered as degenerated or more severely defected forms of teratomas/teratocarcinomas.…”

Section: Tumor Phenotypic Heterogeneitymentioning

confidence: 58%

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Cao

2020

Preprint

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Tumorigenesis is a complex biological phenomenon that includes extensive genetic and phenotypic heterogeneities and complicated regulatory mechanisms. In the recent few years, our studies demonstrate that tumor-initiating cells are similar to neural stem/progenitor cells in regulatory networks, tumorigenicity and pluripotent differentiation potential. In the review, I will make further discussion on these observations and propose a rule of cell biology by integrating these findings with evidence from developmental biology, tumor biology and evolution, which suggests that neural stemness underlies two coupled cell properties, tumorigenicity and pluripotent differentiation potential. Tumorigenicity and phenotypic heterogeneity in tumor is a result of acquirement of neural stemness in cells. The neural stemness property of tumor-initiating cells can hopefully integrate different concepts/hypotheses underlying tumorigenesis. Neural stem cells/neural progenitors and tumor-initiating cells share regulatory networks; both exhibit neural stemness, tumorigenicity and differentiation potential; both are dependent on expression or activation of ancestral genes (the atavistic effect); both rely primarily on aerobic glycolytic metabolism; both can differentiate into various cells or tissues that are derived from three germ layers, resembling severely disorganized or more severely degenerated process of embryonic development; both are enriched in long genes with more splice variants that provide more plastic scaffolds for cell differentiation, etc. The property of neural stemness might be a key point to understand tumorigenesis and pluripotent differentiation potential, and possibly explain certain pathological observations in tumors that have been inexplicable. Therefore, behind the complexity of tumorigenesis might be a general rule of cell biology, i.e., neural stemness represents the ground state of cell tumorigenicity and pluripotent differentiation potential.

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“…Three different hypotheses were formulated, sustaining either an epithelial origin, a mesenchymal origin or a common pluripotent progenitor which undergoes both epithelial and mesenchymal dedifferentiation [ 6 , 17 , 18 ]. Nowadays, the epithelial origin is the most widely accepted, based on the K- ras codon 12 mutation identified in the mononuclear tumor cells – that is one of the driver mutation also present in conventional pancreatic duct adenocarcinoma, and on the retained expression of epithelial markers (CK, EMA) – at least focally [ 19 ]. On the other hand, the vimentin expression in the mononuclear cells of this epithelial tumor sustains the epithelial-mesenchymal transition within the carcinogenic process [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review

et al. 2019

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Undifferentiated carcinoma with osteoclast-like giant cell (UCOGC) is a ductal carcinoma variant with a recently reported more protracted survival and pathognomonic histology comprising two cell populations: the mononuclear tumoral cells and nontumoral multinucleated giant cells. It usually presents as a large heterogenic tumor with mixed solid-cystic components. The tumor develops from the ductal epithelium but the sequence of epithelial changes is often not identified due to the rapid tumoral growth and associated necrotic changes. We report a case of a 76-year-old patient diagnosed with cephalic UCOGC originating in the epithelium of the main pancreatic duct with endoluminal growth and foci of other ductal neoplasms (high-grade pancreatic intraepithelial neoplasia (PanIN) and conventional ductal carcinoma). The particularity of our case consists in the identification of the columnar epithelium conversion, through high-grade PanIN, into UCOGC specific malignant features, in a large size tumor – aspect usually reported in small tumors. Alongside our case we also present a brief literature review of cephalic UCOGC case reports and case series.

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Undifferentiated Pancreatic Carcinoma with Osteoclast-Like Giant Cells: a Case Report

Cited by 11 publications

References 14 publications

Huge and recurrent undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

Huge and recurrent undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review

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