Undifferentiated (embryonal) sarcoma of the liver: Fine-needle aspiration cytology and preoperative chemotherapy as an approach to diagnosis and initial treatment. A case report

Pollono, Daniel; Drut, Ricardo

doi:10.1002/(sici)1097-0339(199808)19:2<102::aid-dc6>3.0.co;2-g

Cited by 20 publications

(12 citation statements)

References 15 publications

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“…Therefore, FNAC plays a pivotal role in establishing an early and accurate diagnosis especially in view of the emergence of neoadjuvant preoperative chemotherapeutic regimes that have shown some success in these tumors. The cytomorphology described here and previously in single case reports [24,25] combined with a good clinico-radiological correlation can ensure an accurate diagnosis.…”

Section: Discussionmentioning

confidence: 58%

Fine needle aspiration biopsy in pediatric space-occupying lesions of liver: a retrospective study evaluating its role and diagnostic efficacy

Bakshi

Srinivasan

Rao

et al. 2006

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 58%

Fine needle aspiration biopsy in pediatric space-occupying lesions of liver: a retrospective study evaluating its role and diagnostic efficacy

Bakshi

Srinivasan

Rao

et al. 2006

Journal of Pediatric Surgery

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“…This is because neo-adjuvant protocols differ from those used to treat HB and HCC. Although UESL can be successfully diagnosed using fine-needle aspiration and percutaneous biopsy, [15] there is a theoretically higher risk of peritoneal and tract seeding. [16] Due to the predominantly cystic nature of UESL, percutaneous biopsy also may not provide representative tissue and an open biopsy is preferred.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20] Liver transplantation has been performed for non-resectable tumours, [21] or for recurrent disease after previous resection, and has been suggested to offer more likelihood of cure than adding radiation. [22] Five such patients have been documented with claimed disease-free survival from 18 months to 5 years.…”

Section: Discussionmentioning

confidence: 99%

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

et al. 2013

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Background. Undifferentiated embryonal sarcoma of the liver (UESL) is a rare neoplasm, and the third-most common paediatric hepatic malignancy. However, no treatment guidelines exist. No randomised, controlled trials support specific combinations of therapy. Objective. To compare presentation and management of UESL with other series, review the literature, and formulate treatment guidelines. Methods. A retrospective chart review of all hepatic malignancies was conducted from 1996 to 2007 and 5 children with UESL were identified. Management and outcomes were documented. The literature regarding treatment modalities up to September 2012 was reviewed. Results. Over a period of 11 years, 5 patients presented. All underwent surgery and 4 received chemotherapy. One received radiotherapy at relapse. Three are disease-free with follow-up of 58 -184 months. One died after relapse, as did the patient whose family declined chemotherapy. Conclusion. The improved outcomes are consistent with the international experience and are probably related to combined treatment modalities and advances in supportive care. Pre-operative percutaneous biopsy provides no benefit if the lesion is resectable because it may not prove to be diagnostic, and may cause recurrence in the biopsy tract. If resectable, the recommended treatment is primary excision and adjuvant chemotherapy, with radiotherapy in selected cases. If unresectable, open biopsy is necessary to document histology, and neoadjuvant chemotherapy is given prior to resection. If deemed unresectable, liver transplantation is considered.

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“…Other mesenchymal lesions of the liver include undifferentiated embryonal sarcoma, which occurs in older children, between 5 and 10 years of age, and on aspiration shows mucoid material, spindled tumour cells and bizarre tumour giant cells. 17,18 Angiosarcoma of the liver is very rare, is usually seen in an older age group and shows a malignant tumour on aspirates with cells that may appear epithelioid or spindle shaped and that show minimal features of vasoformation in the form of lumina. 19,20 Metastatic rhabdomyosarcoma usually involves the lungs rather than the liver, but when seen, may be multifocal in the liver.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology of infantile haemangioendothelioma of the liver: a report of two cases

Sigamani¹,

Iyer²,

Agarwala

2010

Cytopathology

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E. Sigamani, V. K. Iyer and S. Agarwala Fine needle aspiration cytology of infantile haemangioendothelioma of the liver: a report of two cases Background: Fine needle aspiration cytology (FNAC) of infantile haemangioendothelioma of the liver (IHL) has not previously been described because routine use of FNAC is contraindicated due to the risk of bleeding. Methods and materials: Two patients presented with progressively increasing right upper quadrant abdominal mass. The index case was a girl aged two and a half years with a large single mass in the right lobe of the liver. The second was a 3‐month‐old girl in whom ultrasonography revealed multiple hypoechoic lesions in the liver. Ultrasound‐guided fine needle aspiration had been performed on both patients. May‐Grünwald‐Giemsa stained smears from these two patients were reviewed and correlated with histopathology. Results: Both aspirates showed predominantly normal hepatocytes and bile ductules amongst which tumour cells were admixed. The latter were oval to spindle‐shaped with scant cytoplasm and wavy, kinked and indented nuclear outlines. The non‐epithelial character of the tumour cells was apparent and helped to rule out hepatoblastoma. One case showed extramedullary haemopoiesis. The diagnosis of IHL was established on subsequent excision in the first case and a wedge biopsy in the second case. CD34 and factor VIII R antigen were positive in the tumour cells. Conclusion: Radiological diagnosis of IHL is possible in a majority of cases, but sometimes features may overlap with hepatoblastoma and fine needle aspiration may be performed inadvertently. Characteristic kinked nuclei and intermixed normal liver tissue might suggest IHL in the differential diagnosis of a spindle cell vasoformative tumour.

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Undifferentiated (embryonal) sarcoma of the liver: Fine-needle aspiration cytology and preoperative chemotherapy as an approach to diagnosis and initial treatment. A case report

Cited by 20 publications

References 15 publications

Fine needle aspiration biopsy in pediatric space-occupying lesions of liver: a retrospective study evaluating its role and diagnostic efficacy

Fine needle aspiration biopsy in pediatric space-occupying lesions of liver: a retrospective study evaluating its role and diagnostic efficacy

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

Fine needle aspiration cytology of infantile haemangioendothelioma of the liver: a report of two cases

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