Undifferentiated (embryonal) sarcoma of the liver: Combination treatment by surgery and chemotherapy

Kim, Dae-Yeon; Kim, Ki Hong; Jung, Sung-Eun; Lee, Seong-Cheol; Park, Kwi-Won; Kim, Wooki

doi:10.1053/jpsu.2002.35404

Cited by 91 publications

(84 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent articles suggest that the use of multimodal therapy has significantly improved prognosis. [6][7][8] This improvement in outcome may be related to a modern multidisciplinary approach, including potent combinations of neo-adjuvant and adjuvant chemotherapy, radical surgical resection and radiotherapy, and improved supportive care.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20] Liver transplantation has been performed for non-resectable tumours, [21] or for recurrent disease after previous resection, and has been suggested to offer more likelihood of cure than adding radiation. [22] Five such patients have been documented with claimed disease-free survival from 18 months to 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Of these tumours 62% showed reduction in volume following chemotherapy. There are more data on the treatment of patients with sarcoma protocols [7,8,13,14,26,27] than those with hepatoblastoma protocols. [17][18][19]30,31] Such reports do not lend themselves to rigorous statistical analysis, but the relatively high survival rate in patients treated on sarcoma protocols implies acceptable efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Early literature reports a poor prognosis with limited survival, and long-term survival rates are difficult to assess due to relatively short follow-up. Subsequent reports suggest significantly improved prognosis with the use of multimodal therapy, [6][7][8] which may be secondary to one of many factors. Some units favour a sequence of neo-adjuvant chemotherapy, followed by surgery and adjuvant chemotherapy.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

et al. 2013

View full text Add to dashboard Cite

Background. Undifferentiated embryonal sarcoma of the liver (UESL) is a rare neoplasm, and the third-most common paediatric hepatic malignancy. However, no treatment guidelines exist. No randomised, controlled trials support specific combinations of therapy. Objective. To compare presentation and management of UESL with other series, review the literature, and formulate treatment guidelines. Methods. A retrospective chart review of all hepatic malignancies was conducted from 1996 to 2007 and 5 children with UESL were identified. Management and outcomes were documented. The literature regarding treatment modalities up to September 2012 was reviewed. Results. Over a period of 11 years, 5 patients presented. All underwent surgery and 4 received chemotherapy. One received radiotherapy at relapse. Three are disease-free with follow-up of 58 -184 months. One died after relapse, as did the patient whose family declined chemotherapy. Conclusion. The improved outcomes are consistent with the international experience and are probably related to combined treatment modalities and advances in supportive care. Pre-operative percutaneous biopsy provides no benefit if the lesion is resectable because it may not prove to be diagnostic, and may cause recurrence in the biopsy tract. If resectable, the recommended treatment is primary excision and adjuvant chemotherapy, with radiotherapy in selected cases. If unresectable, open biopsy is necessary to document histology, and neoadjuvant chemotherapy is given prior to resection. If deemed unresectable, liver transplantation is considered.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Because ES is rare, no comprehensive data are available regarding the best form of therapy. Liver transplantation for ES is associated with a poor outcome due to recurrent disease in the transplanted liver [3] Chemotherapy has been used in both adjuvant and neoadjuvant settings [4].…”

Section: Discussionmentioning

confidence: 99%

A case of embryonal sarcoma of the liver

Pathirana¹,

Siriwardana

Deen

et al. 2010

Ceylon Med. J.

View full text Add to dashboard Cite

A 32-year old male had a nine month history of worsening right hypochondrial pain, gradual abdominal distension, loss of weight and loss of appetite. On further evaluation his body mass index was 16.9. There was gross hepatomegaly. He was in Child's grade B (low albumin and ascites). Computerised tomography (CT) revealed a massive liver tumour involving segments IV, V, VI and VII (Figure 1). Compensatory hypertrophy was seen in segment II and III. Inferior venacava and the right branch of the portal vein were also compressed by the tumour.

show abstract

Management of primary liver sarcomas

Weitz

Klimstra

Cymes

et al. 2007

Cancer

167

133

View full text Add to dashboard Cite

BACKGROUNDPrimary hepatic sarcoma is a rare entity. The objectives of the study were to define treatment and long‐term outcome and to identify prognostic factors.METHODSBetween January 1981 and December 2004, 30 patients with primary sarcoma of the liver and 5 patients with primary carcinosarcoma of the liver were treated. Patient demographics, tumor characteristics, treatment, and actuarial survival were analyzed.RESULTSOf the 30 patients with primary hepatic sarcoma (10 epithelioid hemangioendothelioma, 5 embryonal sarcoma, 5 angiosarcoma, 3 solitary fibrous tumor, and 7 other types), 11 underwent R0‐resection and had a 5‐year disease‐specific survival of 64%. Of these 11 patients, 4 had low‐grade sarcoma and have not developed tumor recurrence. In the group of 7 patients with high‐grade sarcomas who underwent R0‐resection, both patients with angiosarcoma died within 11 months, whereas the 5 patients with embryonal sarcoma had a 5‐year disease‐free and disease‐specific survival of 80%. Six of the 10 patients with an epithelioid hemangioendothelioma were managed without surgery, as they had diffuse, slowly progressing, or stable lesions; these patients had a 5‐year disease‐specific survival of 67%. Of the remaining 13 patients in whom R0‐resection was not performed, there were no 3‐year survivors. The prognosis for patients with primary carcinosarcoma of the liver was poor, with all but 1 patient dying within a year and no 3‐year survivors.CONCLUSIONSThe outcome of patients with primary hepatic sarcoma depends primarily on tumor histology and the ability to achieve complete tumor resection. Improvements in outcome will require the development of more effective systemic therapies. Cancer 2007. © 2007 American Cancer Society.

show abstract

Undifferentiated (embryonal) sarcoma of the liver: Combination treatment by surgery and chemotherapy

Cited by 91 publications

References 15 publications

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

Management of undifferentiated embryonal sarcoma of the liver in children: A case series and management review

A case of embryonal sarcoma of the liver

Management of primary liver sarcomas

Contact Info

Product

Resources

About