Undifferentiated Connective Tissue Disease: Comprehensive Review

Rubio, Jose; Kyttaris, Vasileios C.

doi:10.1007/s11926-023-01099-5

Cited by 9 publications

(11 citation statements)

References 18 publications

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“…The guidelines for the diagnosis and therapy of UCTD are not well established. Luckily, UCTD tends to respond to steroid taper and/or hydroxychloroquine [ 12 ]. Unfortunately, there are no current guidelines to determine the ideal suppressive therapy for patients with myositis in the setting of a rheumatologic disease [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…When the underlying cause of the myositis is known, a drug targeting the pathologic step in the inflammatory pathway is chosen [13]. While there are some promising results, due to the rarity of myositis in rheumatologic disease, the studies exploring the use of these agents are too small to draw definitive conclusions from [12][13][14]. Applying current literature to this case is difficult due to the diagnostic gray area in which UCTD lies [14].…”

Section: Discussionmentioning

confidence: 99%

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Hyperviscosity Syndrome in Undifferentiated Connective Tissue Disease: A Diagnostic and Therapeutic Challenge

Mines,

Al-Abayechi,

Kaur

et al. 2024

Cureus

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Hyperviscosity is an uncommon manifestation of various underlying diseases. Rapid diagnosis and management of the underlying disease is crucial to prevent significant complications, including hypertension, cerebral vascular accidents, pulmonary embolism, bowel ischemia, and ophthalmologic pathologies. Although the acute management of complications arising from hyperviscosity is relatively straightforward, identifying and treating the underlying cause can prove difficult. This case highlights the difficulties of establishing a diagnosis and initiating appropriate management for a patient with hyperviscosity syndrome in a suspected rheumatologic disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyperviscosity Syndrome in Undifferentiated Connective Tissue Disease: A Diagnostic and Therapeutic Challenge

Mines,

Al-Abayechi,

Kaur

et al. 2024

Cureus

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“…Серед відомих механізмів фіброзувальної дії альдостерону слід виділити гіперекспресію трансформуючого фактора ростуβ та ДНК колагену І типу [30]. Окрім того, у пацієнтів з інфарктом міокарда на тлі недиференційованої дисплазії сполучної тканини альдостерон індукує процеси локального запалення в ендотелії середніх і дрібних вінцевих судин [29,34]. Тому автори припускають, що підвищений рівень альдостерону відіграє роль додаткового чинника ураження вінцевих артерій запального характеру, що прискорює розвиток атеросклеротичного процесу.…”

Section: результати обговоренняunclassified

Etiological and pathomorphological manifestations of atrial fibrillation

Slobodianiuk,

Berezovskyi,

Chernykh

et al. 2024

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Atrial fibrillation is a polyetiological disease caused not only by the natural aging of the population, but also by chronic cardiovascular diseases and the influence of various risk factors. That is why the purpose of this review was to highlight current and modern views on etiological factors that play a significant role in the development of atrial fibrillation. The analysis of scientific articles and materials from the scientometric databases PubMed, Web of Science, Google Scholar, Crossref, WorldCat was carried out. Demonstrated morphological (enlargement and fibrosis of the left atrium, more massive deposition of calcium in the subendothelial layer, and in rare cases, the development of isolated atrial amyloidosis) and electrophysiological changes (reduction of mitochondrial Ca2+ content, shortening of the effective refractory period, impaired repolarization) of the atria of the heart at autopsy patients with atrial fibrillation and established risk factors for the development of this pathology. Morphological signs of atrial myocardium remodeling in patients with atrial fibrillation are also indicated. In addition to the most common risk factors, namely: age, arterial hypertension, heart failure, coronary heart disease, diabetes, obesity and alcohol abuse, the following are highlighted in recent publications: narcotic substances (methamphetamine, cocaine, cannabis), race belonging to Caucasians, sex-specific features (female gender and fluctuations in estrogen levels), genetic predisposition and hyperaldosteronism against the background of undifferentiated connective tissue dysplasia. Optimal and timely treatment aimed at the above-mentioned etiological factors will reduce the risk of developing this disease and improve the quality of life of patients.

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“…While all the aforementioned symptoms are commonly associated with autoimmune disease, the manifestations alone fail to meet the criteria for a defined CTD such as SLE. In cases where the diagnosis remains unclear, undifferentiated CTD (UCTD) is a viable diagnosis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…A definition for UCTD has not been published by either the American College of Rheumatology or the European Alliance of Association for Rheumatology. The widely accepted definition of UCTD stipulates that a patient must exhibit a positive ANA measured on two separate occasions along with at least one clinical symptom of a CTD while still failing to meet the established criteria for a CTD [ 5 ]. Consequently, the management and treatment of this disease varies and lacks specific guidelines.…”

Section: Introductionmentioning

confidence: 99%

A Case Report: Unveiling the Underlying Cause of Recurrent Pericarditis in a Patient With Undifferentiated Connective Tissue Disease

Boever,

Bannis

2024

Cureus

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Undifferentiated connective tissue disease (UCTD) is a condition characterized by symptoms and laboratory findings related to various systematic autoimmune diseases. Severe symptoms like chest pain in patients with UCTD could suggest an underlying secondary condition, such as pericarditis. Our case involves a 36-year-old woman with a history of UCTD and recently diagnosed rheumatoid arthritis (RA) who presented with persistent sub-sternal chest pain and pressure that began three weeks ago. Over the past year, she experienced six similar episodes of chest pain, diagnosed as idiopathic pericarditis. She promptly underwent treatment with oral prednisone and was instructed to continue her current medications (colchicine, methotrexate, and Plaquenil). Subsequent laboratory results, obtained several days posttreatment, revealed an elevated C-reactive protein (CRP), normal erythrocyte sedimentation rate (ESR), an elevated rheumatoid factor, and a normal echocardiogram, suggesting resolution of the acute flare. Despite having a comprehensive treatment regimen, the patient continues to experience recurrent pericarditis episodes. The cause of the recurrence remains uncertain, potentially associated with repeated use of high-dose steroids and a recent diagnosis of RA. Consequently, her rheumatologist opted to initiate treatment with intravenous Golimumab to better manage the RA and potentially address recurrent pericarditis. Physicians should maintain a heightened clinical suspicion of pericarditis in UCTD patients experiencing chest pain, as initiating prompt treatment helps prevent long-term complications and can be lifesaving in certain instances.

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Undifferentiated Connective Tissue Disease: Comprehensive Review

Cited by 9 publications

References 18 publications

Hyperviscosity Syndrome in Undifferentiated Connective Tissue Disease: A Diagnostic and Therapeutic Challenge

Hyperviscosity Syndrome in Undifferentiated Connective Tissue Disease: A Diagnostic and Therapeutic Challenge

Etiological and pathomorphological manifestations of atrial fibrillation

A Case Report: Unveiling the Underlying Cause of Recurrent Pericarditis in a Patient With Undifferentiated Connective Tissue Disease

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