Undifferentiated Carcinoma With Osteoclast-Like Giant Cells: A Rare Cause of Upper Gastrointestinal Bleeding

Abstract

Undifferentiated osteoclast-like giant cell carcinomas (UOLGCCs) of the digestive tract are very rare, with only a few cases reported in the literature. An 82-year-old man was referred to the emergency department for melena. Endoscopic examination revealed a hemicircumferential ulcerovegetative lesion, involving the bulbar apex and extending to the second portion of the duodenum; biopsies revealed an UOLGCC. The patient underwent transfusion support therapy, and he was proposed for best supportive care. Duodenal UOLGCC is an extremely rare cause of upper gastrointestinal bleeding. Clinical findings and therapeutic approach represent a challenge in this pathology.

Undifferentiated carcinoma of the liver with osteoclast-like giant cells: a case report and literature review

“…Carcinomas with osteoclast-like giant cells (OGCs) occasionally occur in a variety of sites such as pancreatic [ 3 ], ampullary [ 4 ], duodenal [ 5 ], gastric [ 6 ], gallbladder [ 7 ], thyroid [ 8 ], breast [ 9 ], lung [ 10 ], urinary bladder [ 11 ], ureter [ 12 ], kidney [ 13 ], cutaneous [ 14 ], parotid gland [ 15 ], renal pelvis [ 16 ], salivary [ 17 ], ovary [ 18 ], and liver [ 19 ], with pancreatic tumors being the most common. The presence of OGCs in HCC is extremely rare, and there have been relatively few clinical reports.…”