Understanding YTHDF2-mediated mRNA degradation by m6A-BERT-Deg
Ting-He Zhang,
Sumin Jo,
Michelle Zhang
et al.
Abstract:N6-methyladenosine (m6A) is the most abundant mRNA modification within mammalian cells, holding pivotal significance in the regulation of mRNA stability, translation and splicing. Furthermore, it plays a critical role in the regulation of RNA degradation by primarily recruiting the YTHDF2 reader protein. However, the selective regulation of mRNA decay of the m6A-methylated mRNA through YTHDF2 binding is poorly understood. To improve our understanding, we developed m6A-BERT-Deg, a BERT model adapted for predict… Show more
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