Understanding Why and When Optical Coherence Tomography Does Not Detect Vulnerable Plaques

Mintz, Gary S.

doi:10.1161/circinterventions.116.004144

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…VH-IVUS sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. In recent years, optical coherence tomography (OCT) has emerged as an imaging modality to identify vulnerable plaques from nonvulnerable plaques to enhance future risk prediction [12][13][14][15][16][17]. OCT has resolution of 15-20 lm and therefore can better measure fibrous cap thickness and can detect plaque rupture and other ruptureprone features in patients.…”

Section: Introductionmentioning

confidence: 99%

Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

Guo

Giddens

Molony

et al. 2018

Journal of Biomechanical Engineering

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Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were acquired with informed consent obtained. IVUS and OCT images were merged to form the IVUS + OCT data set, with biplane angiography providing three-dimensional (3D) vessel curvature. For components where VH-IVUS set zero cap thickness (i.e., no cap), a cap was added with minimum cap thickness set as 50 and 180 μm to generate IVUS50 and IVUS180 data sets for model construction, respectively. 3D fluid-structure interaction (FSI) models based on IVUS + OCT, IVUS50, and IVUS180 data sets were constructed to investigate cap thickness impact on stress/strain calculations. Compared to IVUS + OCT, IVUS50 underestimated mean cap thickness (27 slices) by 34.5%, overestimated mean cap stress by 45.8%, (96.4 versus 66.1 kPa). IVUS50 maximum cap stress was 59.2% higher than that from IVUS + OCT model (564.2 versus 354.5 kPa). Differences between IVUS and IVUS + OCT models for cap strain and flow shear stress (FSS) were modest (cap strain <12%; FSS <6%). IVUS + OCT data and models could provide more accurate cap thickness and stress/strain calculations which will serve as basis for further plaque investigations.

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Section: Introductionmentioning

confidence: 99%

Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

Guo

Giddens

Molony

et al. 2018

Journal of Biomechanical Engineering

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“…Pathological studies showed that large lipid core and thin fibrous cap are closely related to high-risk vulnerable plaques [46]. Since lipid core size and fibrous cap thickness are measurable from in vivo images, some preliminary studies attempted to assess plaque vulnerability from a mechanical perspective as surrogates for plaque vulnerability [21,22,40].…”

Section: Plaque Rupture and Plaque Vulnerability Assessmentmentioning

confidence: 99%

Image-based biomechanical modeling for coronary atherosclerotic plaque progression and vulnerability prediction

Wang

Maehara

et al. 2022

International Journal of Cardiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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The Integration of IVUS and OCT

Zhou

et al. 2019

Multimodality Imaging

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Understanding Why and When Optical Coherence Tomography Does Not Detect Vulnerable Plaques

Cited by 4 publications

References 34 publications

Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

Image-based biomechanical modeling for coronary atherosclerotic plaque progression and vulnerability prediction

The Integration of IVUS and OCT

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