Understanding Trabecular Meshwork Physiology: A Key to the Control of Intraocular Pressure?

Llobet, Artur; Gasull, Xavier; Gual, Arcadi

doi:10.1152/nips.01443.2003

Cited by 86 publications

(111 citation statements)

References 10 publications

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“…in these cell types was found to be similar for all viruses examined (data not shown) (8,13). To examine the possibility of intraocular influenza virus replication, we additionally infected human trabecular meshwork cells (HTMC), fibroblasts located in the anterior chamber angle of the eye which are exposed to draining aqueous fluid (32). The replication kinetics for each virus were generally found to be similar in all ocular cell types examined.…”

Section: Resultsmentioning

confidence: 90%

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Belser

Zeng

Katz

et al. 2011

J Virol

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Section: Resultsmentioning

confidence: 90%

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Belser

Zeng

Katz

et al. 2011

J Virol

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“…However, its direct and short-term effects on IOP regulation remain poorly understood 1 . Chronic exposure to pigment 7 , erythrocyte-derived ghost cells 8 , inflammatory cells 9 , photoreceptor outer segments 10 , lens and pseudoexfoliation material 11,12 can lead to secondary glaucomas.…”

Section: Introductionmentioning

confidence: 99%

Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma

et al. 2018

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Outflow regulation and phagocytosis are key functions of the Background: trabecular meshwork (TM), but it is not clear how the two are related in secondary open angle glaucomas characterized by an increased particle load. We hypothesized that diminished TM phagocytosis is not the primary cause of early ocular hypertension and recreated pigment dispersion in a porcine ex vivo model.Sixteen porcine anterior chamber cultures received a continuous Methods: infusion of pigment granules (Pg), while 16 additional anterior chambers served as controls (C). Pressure transducers recorded the intraocular pressure (IOP). The phagocytic capacity of the trabecular meshwork was determined by fluorescent microspheres.The baseline IOPs in Pg and C were similar ( =0.82). A significant Results: P IOP elevation occurred in Pg at 48, 120, and 180 hours (all <0.01, compared P to baseline). The pigment did not cause a reduction in TM phagocytosis at 48 hours, when the earliest IOP elevation occurred, but at 120 hours onward (P =0.001 compared to C). This reduction did not result in an additional IOP increase at 120 or 180 hours compared to the first IOP elevation at 48 hours (P >0.05).In this porcine model of pigmentary glaucoma, an IOP elevation Conclusions: occurs much earlier than when phagocytosis fails, suggesting that two separate mechanisms might be at work.

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“…TM is a complex multilayer structure that regulates aqueous outflow in a pressure dependent fashion [24]. In glaucomatous eyes, diseased TM has a reduced facility and shows reduced phagocytosis [25,26], increased stiffness [27], and stress fiber formation [26].…”

Section: Discussionmentioning

confidence: 99%

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Dang¹,

Wang²,

Cen³

et al. 2018

Preprint

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To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open-angle glaucoma (POAG) patients. This was a multicenter, retrospective study and included POAG patients with or without visually-significant cataracts. The primary outcome was intraocular pressure (IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2-years. Success was defined as: 1) IOP < 21 mmHg and at least 20% IOP reduction from baseline after 3 months at any two consecutive visits, and 2) no additional glaucoma surgery required. A total of 42 patients were enrolled; thirteen had a history of failed glaucoma surgery. Twelve patients underwent Trabectome surgery combined with phacoemulsification while the remainder underwent Trabectome surgery alone. Overall, the mean preoperative IOP was 21.4±1.23 mmHg. The Trabectome lowered IOP to 18.5± 0.94 mmHg at 2 years (P<0.05). The number of glaucoma medications also decreased from a baseline of 2.0±0.9 to 1.2± 0.21 at 2 years (P=0.04). The overall success was 78%, with patients undergoing combined surgery having a higher success than those with Trabectome surgery alone (100% vs. 76%). No major complications were seen. The Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the longterm.

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Understanding Trabecular Meshwork Physiology: A Key to the Control of Intraocular Pressure?

Cited by 86 publications

References 10 publications

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

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