Understanding therapeutic hypothermia

Yacono, Christian S; Eider, Stephanie

doi:10.1097/01.jaa.0000511792.75301.73

Cited by 10 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to reduced cytokine and MPO release, hypothermia may have extended survival through additional mechanisms, such as reduced cellular metabolism, reduced oxygen consumption, and minimization of cellular hypoxia, all of which have been shown to contribute to neuroprotection during cardiac resuscitation. 27,28 …”

Section: Discussionmentioning

confidence: 99%

Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats

Willis

Charles

Guidry

et al. 2017

Journal of Surgical Research

View full text Add to dashboard Cite

Background Therapeutic hypothermia in severe septic shock is associated with prolonged survival. We hypothesized that moderate hypothermia would prolong survival and modulate the inflammatory response in rats with septic shock by exerting its therapeutic effect on splenic leukocytes. Materials and Methods Severe septic shock was created in rats by cecal ligation and incision (CLI). One hour after CLI or laparotomy, rats were randomized to sham, normothermia (NT), or 4 hours of hypothermia (HT) followed by 2 hours of rewarming. Hypothermia (3l±1°C) was induced using a cooling blanket, and monitored via a rectal temperature probe. Results Survival duration was 2.78±1.0 hours in NT rats and 8.33±0.32 hours in HT rats (n=8/group, p<0.0001). In separate groups, three hours after CLI, the spleen weight was significantly smaller in NT rats (769±100 mg) than in HT rats (947±157 mg, p=0.04). Fluorescent immunostaining of formyl peptide receptors (FPR) on leukocytes in spleen tissue showed considerably higher FPR expression in HT rats than in NT rats. Significantly elevated pro-inflammatory cytokines and myeloperoxidase (MPO) enzyme in plasma were found in NT rats compared with HT rats. Anti-inflammatory cytokine, IL-10, was significantly higher in HT rats. Both pro-inflammatory cytokines and plasma MPO were significantly reduced in splenectomized NT rats. Conclusions Moderate hypothermic therapy significantly prolongs the survival duration of rats with severe septic shock. Hypothermia dampens the inflammatory response during septic shock by modulating the spleen to an anti-inflammatory mode and preventing the spleen from releasing activated splenic leukocytes into the blood.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats

Willis

Charles

Guidry

et al. 2017

Journal of Surgical Research

View full text Add to dashboard Cite

show abstract

“…See Table 2 for the statement that corresponds to each numbered point. (b) The computergenerated 5-cluster map was developed using hierarchal cluster analysis, the participant-developed 5-cluster map was created when participants moved statements during the mapping session and named each cluster One of the key enablers of Jones and colleagues' success was co-designing the intervention with providers to ensure the screening tool and the components of the screening process met their clinical needs (Damschroder et al, 2009;Jones et al, 2018). Within our study, participants felt that they lacked knowledge about existing screening tools.…”

Section: Discussionmentioning

confidence: 99%

“…Of the five clusters identified by participants in the concept map, staff skills and training and screening tools were rated as relatively more important and more realistic compared to the other three clusters. In previous research, the use of screening tools and enhancement of staff skills and training in primary care settings has shown positive outcomes for screening of other non‐gambling related health behaviours (Jones, Johnston, Biola, Gomez, & Crowder, ; Moyer, ). For example, a recent quality improvement initiative in the United States successfully implemented a screening tool in primary care for alcohol and substance use disorders (Jones et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…One of the key enablers of Jones and colleagues' success was co‐designing the intervention with providers to ensure the screening tool and the components of the screening process met their clinical needs (Damschroder et al, ; Jones et al, ). Within our study, participants felt that they lacked knowledge about existing screening tools.…”

Section: Discussionmentioning

confidence: 99%

“…In previous research, the use of screening tools and enhancement of staff skills and training in primary care settings has shown positive outcomes for screening of other non-gambling related health behaviours (Jones, Johnston, Biola, Gomez, & Crowder, 2018;Moyer, 2013). For example, a recent quality improvement initiative in the United States successfully implemented a screening tool in primary care for alcohol and substance use disorders (Jones et al, 2018). By creating a standardised screening tool and providing tailored educational training for providers, Jones and colleagues found that screening for alcohol and substance use increased to 30,611 assessments from 787 in the year F I G U R E 1 (a) Each point refers to a specific statement.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Factors related to screening for problem gambling among healthcare and social service providers in Ontario, Canada: A concept mapping study

Guilcher

Cadel

Everall

et al. 2020

Health Soc Care Community

View full text Add to dashboard Cite

Problem gambling is a major public health concern, especially among persons who are precariously housed, living in poverty or have complex health and social needs. Problem gambling has been connected to negative health and social outcomes; however, current healthcare services rarely screen for problem gambling. With support from community partners, the purpose of this study was to understand factors related to screening for problem gambling. Concept mapping, a mixed‐method approach driven by participatory involvement, was conducted with healthcare and social service providers from Ontario, Canada in 2019. Three phases were conducted with participants either in‐person or online: Brainstorming, Sorting/Rating and Mapping. Brainstorming sessions were conducted to generate statements, guided by the focal prompt: “If you were directed to routinely screen for problem gambling, what would help you do this in your daily practice?” Participants sorted statements into categories and rated them based on their importance and feasibility. A mapping session was conducted with participants to co‐create visual representations of the data. Thirty participants took part in the in‐person or online concept mapping sessions. During the brainstorming sessions, participants generated 213 statements, which the research team condensed into a final list of 45 statements. Participants decided that the five‐cluster map best represented these 45 statements and labelled the five clusters: (a) top level (macro), (b) screening tool, (c) staff skills and training, (d) screening, and (e) team resources and support. Staff skills and training was rated as the most important and the most realistic cluster to implement, while screening was rated relatively as the least important when compared to the other clusters. Team resources and support was rated relatively as the least realistic cluster. By identifying the needs of healthcare and social service providers, this study co‐developed actionable suggestions that will assist providers in routinely screening for problem gambling.

show abstract

Therapeutic donor hypothermia following brain death to improve the quality of transplanted organs

Hoather

Tingle

Thompson

2023

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Understanding therapeutic hypothermia

Cited by 10 publications

References 31 publications

Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats

Effect of hypothermia on splenic leukocyte modulation and survival duration in severely septic rats

Factors related to screening for problem gambling among healthcare and social service providers in Ontario, Canada: A concept mapping study

Therapeutic donor hypothermia following brain death to improve the quality of transplanted organs

Contact Info

Product

Resources

About