Understanding the Synergistic Correlation between the Spatial Distribution of Drug-Loaded Mixed Micellar Systems and In Vitro Behavior via Experimental and Computational Approaches
Abstract:To
better promote the application of polymeric mixed micelles (PMMs),
a coarse-grained molecular dynamics simulation (CGMD) has been employed
to investigate the factors controlling the spatial distribution within
the PMMs and predict their drug-loading properties, meanwhile, combined
with experimental methods to validate and examine it. In this study,
the snapshots obtained from CGMD and the results of proton nuclear
magnetic resonance (1H NMR) and transmission electron microscopy
(TEM) provide new insights in… Show more
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