Understanding the Significance of Microwave Radiation for the Graft Copolymerization of Acrylamide on Carboxymethyl Xanthan Gum

Badwaik, Hemant; Alexander, Amit; Sakure, Kalyani

doi:10.2174/2213335606666190307162901

Cited by 7 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ammonium persulfate was used as a free radical activator in the microwave-assisted synthesis of carboxymethyl xanthan-gum-grafted polyacrylamide (CM-XG-g-pAA) copolymer. Synthesized nontoxic graft copolymers have better antibacterial efficacy than CM-XG [ 57 ].…”

Section: Derivatives Of Carboxymethylated Gums (Cmgs)mentioning

confidence: 99%

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Baghel¹,

Sakure²,

Giri

et al. 2023

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.

show abstract

Section: Derivatives Of Carboxymethylated Gums (Cmgs)mentioning

confidence: 99%

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Baghel¹,

Sakure²,

Giri

et al. 2023

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

show abstract

“…The copolymerization of NIPAM with MAM increases cationic centers on the macromelecules, consequently, the net positive charge of the molecules is strengthened because of the protonated C=O and NH groups. [47,48]…”

Section: Determination Of the Antibacterial Activitymentioning

confidence: 99%

P(NIPAM–co-MAM) Kopolimer Bitim İşlemi ile Sıcaklığa ve pH'a Duyarlı Akıllı Pamuklu Kumaşların Geliştirilmesi

Genç¹,

Aksoy²

2022

Tekstil Ve Konfeksiyon

View full text Add to dashboard Cite

In this study, fabrication of smart polymer and cotton fabrics with temperature-and pH-responsive as well as antibacterial activity was aimed. For this aim, random poly(N-isopropylacrylamide-comethacrylamide) P(NIPAM-co-MAM) copolymers containing different ratio of NIPAM/MAM monomers were synthesized through free radical addition polymerization method via 2,2'-azobis (2 methylpropionamide) dihydrochloride as an initiator. Analysis results showed that the copolymers were synthesized successfully and their LCST values were in the range of 33°C to 41°C. A selected sample of the synthesized copolymers was applied to the cotton fabric via double-bath impregnation method and thermo-responsive wetting property of the fabric was examined via wetting time and water uptake tests, contact angle measurement. The test results indicated that hydrophilic character of the fabric changed to the hydrophobic character reversibly depending on change in temperature. Besides, the fabric exhibited pH-responsive water absorption ability. The fabric could manage water vapor permeability via changing its pore size as well as hydrophilic character depending on temperature. Besides, it was concluded that the fabric had strong antibacterial activity against S.aureus bacteria.

show abstract

“…As a result, gum reactivity increases. [14] The process is easy and introduces carboxymethyl group to the polymer backbone by using Williamson's reaction. Carboxymethylation can result in a variety of positive benefits at the cost of inexpensive materials.…”

Section: Introductionmentioning

confidence: 99%

“…When the carboxylic group ionized on the gum chain, a negative charge is introduced, thereby attracting the initiator ions to the gum molecules and forming more active reactions for the monomer. As a result, gum reactivity increases [14] . The process is easy and introduces carboxymethyl group to the polymer backbone by using Williamson's reaction.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Carboxymethylated Locust Bean Gum‐co‐poly(SA)‐cl‐poly(MBA) pH Responsive Hydrogel for Controlled Drug Delivery of Metformin Hydrochloride

Tanwar,

Rani,

Gupta

2023

ChemistrySelect

View full text Add to dashboard Cite

The development of hydrophilic carriers with dual stimuli‐ responsiveness for the drug encapsulation and controlled release is one of the biggest challenges for the modern medicinal chemist. In this context, the current study explores the application of locust bean gum (LB), to develop a pH and temperature responsive matrix for controlled delivery of an anti‐diabetic drug, Metformin HCl (MFH) for the first time. LB gum was first structurally modified to carboxymethylated locust bean gum (CMLB). It was copolymerized with sodium acrylate (SA) and cross‐linked by using N,N‐methylene bisacrylamide (MBA) to form hydrogel (CMLB‐co‐poly(SA)‐cl‐poly(MBA)). The model hydrogel was examined using FTIR, TGA, SEM, XRD, and 13C‐NMR to determine structural changes, thermal behaviour and surface morphology. Network parameters confirm the porous nature of the hydrogel and support their swelling behaviour. The drug loaded CMLB‐co‐poly(SA)‐cl‐poly(MBA) hydrogel follows the non‐Fickian diffusion of the anti‐diabetic drug, Metformin HCl (MFH), which is having short and biological half life time. The MFH release profile was analysed by fitting data in the Korsmeyer‐Peppas kinetic model with high rate of release in pH 7.4 compared to Distilled Water (DW) and pH 2.2. Thus we can explore the bio‐compatible synthesized hydrogel as a carrier for sustained drug delivery.

show abstract

Understanding the Significance of Microwave Radiation for the Graft Copolymerization of Acrylamide on Carboxymethyl Xanthan Gum

Cited by 7 publications

References 28 publications

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

P(NIPAM–co-MAM) Kopolimer Bitim İşlemi ile Sıcaklığa ve pH'a Duyarlı Akıllı Pamuklu Kumaşların Geliştirilmesi

Synthesis and Characterization of Carboxymethylated Locust Bean Gum‐co‐poly(SA)‐cl‐poly(MBA) pH Responsive Hydrogel for Controlled Drug Delivery of Metformin Hydrochloride

Contact Info

Product

Resources

About