Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

Mateen, Somaiya; Zafar, Atif; Moin, Shagufta; Khan, Abdul Qayyum; Zubair, Swaleha

doi:10.1016/j.cca.2016.02.010

Cited by 353 publications

(271 citation statements)

References 78 publications

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“…An increased prevalence of traditional risk factors, such as diabetes mellitus, hypertension, obesity, smoking, and physical inactivity, may explain, in part, this excess cardiovascular risk in RA 8, 11. However, innate as well as adaptive immune mechanisms shared by RA and cardiovascular disease, namely atherosclerosis, have emerged as potential contributors to the heightened cardiovascular risk observed in these patients 43, 44…”

Section: Discussionmentioning

confidence: 99%

Incident Heart Failure in Patients With Rheumatoid Arthritis: A Nationwide Cohort Study

Khalid

Egeberg

Ahlehoff

et al. 2018

JAHA

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BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease associated with a wide range of comorbidities, including cardiovascular disease, but its association with heart failure (HF) is not fully clear. We investigated the risk of incident HF in a nationwide cohort of patients with RA.Methods and ResultsThe study comprised the entire Danish population aged ≥18 years followed from January 1, 2008 until first hospitalization for HF, emigration, December 31, 2012, or death. Information on comorbidity, medication, and socioeconomic status was identified by individual‐level linkage of administrative registers. Patients with a rheumatologist diagnosis of RA between 1978 and 2008 were included. The primary study outcome was incident HF defined as first hospital admission for HF. Incidence rates of HF per 1000 person‐years were calculated and incidence rate ratios adjusted for age, sex, calendar year, comorbidity, medications, socioeconomic status, smoking, and alcohol consumption were estimated. A total of 4 305 225 subjects with no history of HF were eligible for analysis at the study start. Of these subjects, 24 343 developed RA and 50 623 were hospitalized for HF. Overall incidence rates of incident HF were 2.43 and 6.64 for the reference population (n=49 879) and patients with RA (n=744), respectively. Correspondingly, the fully adjusted incidence rate ratio for incident HF was increased in patients with RA with incidence rate ratio 1.30 (95% confidence interval, 1.17–1.45).ConclusionsIn this cohort study, RA was associated with an increased hospitalization for HF. These findings add significantly to the existing evidence of RA as a clinically relevant risk factor for HF.

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Section: Discussionmentioning

confidence: 99%

Incident Heart Failure in Patients With Rheumatoid Arthritis: A Nationwide Cohort Study

Khalid

Egeberg

Ahlehoff

et al. 2018

JAHA

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“…This disease presents a variety of systemic manifestations being the persistent inflammatory synovitis the most typical feature, compromising peripheral joints in a symmetric distribution. Mateen et al (2016) [2] highlights RA as a disease, which is characterized in the majority of patients by the presence of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA). The authors reinforce that cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IL-17 have an important role in the pathophysiology of RA since serum concentrations of these substances may indicate the severity of the disease.…”

Section: Introductionmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

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Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

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“…synovitis) and results in cartilage and bone destruction. Both innate and adaptive immune responses are involved in the inflammatory process, in which cytokines play important role in the inflammation and advancing the disease [5].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression of Tumor Necrosis Factor-Alpha in Etanercept-Treated Rheumatoid Arthritis Patients

Mahmood¹,

Al-Kazaz²,

Ad’hiah³

et al. 2017

JBM

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Fifty-one rheumatoid arthritis (RA) patients were enrolled to assess the gene expression of tumor necrosis factor-alpha (TNF-α) by reverse transcription quantitative polymerase chain reaction (qRT-PCR) in etanercept-treated RA patients, with some emphasis on clinical and biological markers of disease. The results revealed that the ∆Ct mean range in total, male and female RA patients and controls was 1.286 ± 1.226 -4.023 ± 0.856 and the differences were not. Laboratory and clinical findings in subgroups of patients also showed no significant variations in the distribution of 2 −∆∆Ct means, with the exception of anti-cyclic citrullinated peptide (ACCP) antibodies. The lowest expression was observed in moderate positive patients (1.566 ± 1.104) compared to low and high positive patients (4.061 ± 1.366 and 9.668 ± 3.518, respectively) for ACCP antibodies, and the difference was significant (p = 0.043). Inspecting the 2 −∆∆Ct means in duration of disease and gender revealed that male patients recorded a lower mean than female patients (0.827 ± 0.550 vs. 4.143 ± 1.317) at <5 years disease duration, while at >10 years duration of disease, female patients showed a lower mean than male patients (1.242 ± 0.372 vs. 5.607 ± 3.334). However, both differences were not significant. It is concluded that etanercept was effective in normalizing the TNF gene expression, but variations that were related to gender, duration of disease and some biological markers of disease, were observed.

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Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

Cited by 353 publications

References 78 publications

Incident Heart Failure in Patients With Rheumatoid Arthritis: A Nationwide Cohort Study

Incident Heart Failure in Patients With Rheumatoid Arthritis: A Nationwide Cohort Study

Adipokines in rheumatoid arthritis

Gene Expression of Tumor Necrosis Factor-Alpha in Etanercept-Treated Rheumatoid Arthritis Patients

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