Understanding the role of 3-O-Acetyl-11-keto-β-boswellic acid in conditions of oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity

Protective role of AKBA against benzo(a)pyrene‐induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress

“…The decrease in body weights of rats could be attributed to BaP observed in earlier studies related to BaP from our lab. [29] Further, from the results it is clearly evident that BaP treatment elevated the levels of Phase I biotransformation enzymes Cyt P 450 , Cyt b5, and AHH and inhibited Phase II GST enzyme. BaP is oxidized by Cyt P 450 family enzymes which leads to generation of various metabolites including BaP-7, 8 oxide, which upon further metabolism by epoxide hydrolase 1 produces BaP 7-8 diol.…”

“…[14,20] Recent in vivo and in vitro studies have shown AKBA to possess antiinflammatory, antioxidant, antiproliferative and antitumor activities. [22,25,29,32] Therefore, the present study was planned to elucidate the role of AKBA on biotransformation enzymes and oxidative stress markers, which are the key players in lung carcinogenesis induced with BaP.…”

“…[27,28] Earlier, we have investigated AKBA antioxidant activity against BaP induced hepatotoxicity. [29] Further, AKBA has been reported to possess anticancer activity by way of inhibiting cell viability, cell proliferation and to induce apoptosis in conditions of colorectal, pancreatic and gastric cancers investigated. [30][31][32] Therefore, the current study was designed to explore the mechanisms involved on the chemopreventive role of AKBA in the initiation process of lung carcinogenesis induced by BaP in rats.…”

Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight

“…Noteworthy, our new findings of these hepatoprotective actions of BAs in an experimentally-induced ALD added to other research on its preventative effects in other liver diseases. For example, earlier studies stated that BAs ameliorated multiple agents-induced hepatotoxicity models via reducing the expression of hepatic transforming growth factor beta, phosphorylated c-Jun N-terminal kinase, TNF-α, NFκB, and IL-6, while enhancing the nuclear factor E2-related factor 2/heme oxygenase 1 axis (Chen et al 2017 ; Kumar et al 2017 ; Barakat et al 2018 ; Eltahir et al 2020 ). Meanwhile, in a non-alcoholic fatty liver experimental model, BAs restored the reduced glutathione, and diminished MDA levels and other inflammatory mediators as TNF-α, IL-6, cyclooxygenase 2, and inducible nitric oxide synthase in hepatic tissues (Zaitone et al 2015 ).…”

3-Acetyl-11-keto-β-boswellic Acid-Based Hybrids Alleviate Acetaminophen-Induced Hepatotoxicity in HepG2 by the Regulation of Inflammatory and Oxidative Stress Pathways: An Integrated Approach

“…In this context, oleogum resin from frankincense was reported to possess hepatoprotective properties; − among its constituents, boswellic acids are extensively studied, especially 3-acetyl-11-keto-β-boswellic acid (AKBA), which emerged as a potent anti-inflammatory agents − Moreover, AKBA is known to bind to receptors in bile and help in restoration of liver normal architecture . So, hybrid pharmacological agents could serve as a promising solution to multifaced conditions such as drug-induced hepatitis, which affects the lifestyle of thousands of patients and may develop into life-threatening situations.…”