Understanding the Relationship Between Age and Thyroid Cancer

Haymart, Megan R.

doi:10.1634/theoncologist.2008-0194

Cited by 111 publications

(87 citation statements)

References 32 publications

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“…As an exception, we identified age‐associated dmCpGs in thyroid tumors. Uncommonly, thyroid cancer includes age as a prognostic indicator in most staging systems (Haymart, 2009), implying that these cancers do suffer age‐related changes in their behavior. Intriguingly, this tissue displayed the lowest level of DNA methylation changes in cancer and one of the lowest in aging.…”

Section: Discussionmentioning

confidence: 99%

Distinct chromatin signatures of DNA hypomethylation in aging and cancer

et al. 2018

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SummaryCancer is an aging‐associated disease, but the underlying molecular links between these processes are still largely unknown. Gene promoters that become hypermethylated in aging and cancer share a common chromatin signature in ES cells. In addition, there is also global DNA hypomethylation in both processes. However, the similarity of the regions where this loss of DNA methylation occurs is currently not well characterized, and it is unknown if such regions also share a common chromatin signature in aging and cancer. To address this issue, we analyzed TCGA DNA methylation data from a total of 2,311 samples, including control and cancer cases from patients with breast, kidney, thyroid, skin, brain, and lung tumors and healthy blood, and integrated the results with histone, chromatin state, and transcription factor binding site data from the NIH Roadmap Epigenomics and ENCODE projects. We identified 98,857 CpG sites differentially methylated in aging and 286,746 in cancer. Hyper‐ and hypomethylated changes in both processes each had a similar genomic distribution across tissues and displayed tissue‐independent alterations. The identified hypermethylated regions in aging and cancer shared a similar bivalent chromatin signature. In contrast, hypomethylated DNA sequences occurred in very different chromatin contexts. DNA hypomethylated sequences were enriched at genomic regions marked with the activating histone posttranslational modification H3K4me1 in aging, while in cancer, loss of DNA methylation was primarily associated with the repressive H3K9me3 mark. Our results suggest that the role of DNA methylation as a molecular link between aging and cancer is more complex than previously thought.

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Section: Discussionmentioning

confidence: 99%

Distinct chromatin signatures of DNA hypomethylation in aging and cancer

et al. 2018

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“…Unique among all malignancies, the majority of staging systems for well-differentiated thyroid cancers includes age as one of the key prognostic factors (Dean & Hay 2000, Haymart 2009). In iodine-replete healthy adult populations, such as the cohort investigated by Haymart et al (2008a), there is an increase in serum TSH with advancing age (Surks & Hollowell 2007, Haymart et al 2008b.…”

Section: Association Between Serum Tsh and Differentiated Thyroid Canmentioning

confidence: 99%

The association between serum TSH concentration and thyroid cancer

Boelaert

2009

Endocrine-Related Cancer

125

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There is mounting evidence that the serum concentration of TSH is an independent predictor for the diagnosis of thyroid malignancy in patients with nodular thyroid disease. Furthermore, preoperative serum TSH concentrations are higher in patients with more aggressive tumours, suggesting a potential role for TSH in the progression of differentiated thyroid cancer. Based on these observations, patients with higher serum TSH concentrations and borderline cytological results may require more aggressive investigation and treatment when compared with those with lower baseline TSH levels. The mechanisms underlying the finding of higher serum TSH in patients with thyroid cancer remain unexplained. In this issue of Endocrine-Related Cancer, Fiore et al. have analysed the relationship between serum TSH and diagnosis of papillary thyroid cancer in 10 178 patients with nodular thyroid disease who were investigated by fine-needle aspiration biopsy. They found significantly higher TSH concentrations in patients who were subsequently diagnosed with thyroid cancer compared with those with benign disease. In addition, they found that the development of autonomous thyroid function (TSH!0.4 mU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context.

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“…Differentiated thyroid carcinoma (DTC) is generally associated with a favorable prognosis, with the ten-year survival rate reaching 90%-95% (Schlumberger and Torlontano, 2000), but the mortality rate climbs gradually from the age of 40-45 years (Haymart, 2009). Subjects with DTC remain at risk of tumor recurrence/persistence for decades after diagnosis, which highlights the importance of long-term followup (Pacini et al, 2010;Tala and Tuttle, 2010).…”

Section: Introductionmentioning

confidence: 99%

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Giusti

Melle

Fenocchio

et al. 2011

J. Zhejiang Univ. Sci. B

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Differentiated thyroid carcinoma (DTC) generally has a favorable outcome. Thyroid disease, treatments, stress, and comorbidity can compromise health-related quality of life (QoL) and indirectly weigh upon the outcome. From 2004 to 2008, we evaluated QoL longitudinally in 128 DTC subjects. During scheduled examinations, subjects were asked to undergo a semi-structured psychiatric interview and five rated inventories. The same examination was conducted in 219 subjects after surgery for benign thyroid pathology. Low scores represent a better QoL. DTC and control subjects were similar in terms of age, male/female ratio, concomitant psychopharmacological treatments, and frequency of psychiatric diseases. In DTC subjects, Billewicz scale (BS) scores showed an increasing trend over time, especially among females. The ad hoc thyroid questionnaire (TQ) scores were similar in both groups and did not change over time, but at the end of the study ad hoc TQ and BS were significantly related. Ad hoc TQ scores were also related to age on entry to the study. In both male and female DTC subjects, Hamilton's tests for anxiety (HAM-A), but not for depression (HAM-D), showed an improving trend. At the end of the study, HAM-A and HAM-D scores were comparable to those of the control group. HAM-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and treatment. Only HAM-D correlated with age on entry to the study. Kellner symptom questionnaire (KSQ) item scores were higher in DTC subjects than in controls. The change over time in the items including anxiety, somatization, depression, and hostility was significant. Somatization and hostility were more significantly reduced in DTC females than in DTC males. Hostility scores were significantly lower in DTC subjects than in controls at the end of the study. Somatization and depression were significantly related to staging on diagnosis and age on entry to the study. Our study confirms a wide variation of illness perception in DTC subjects, which is generally unrelated to the favorable clinical follow-up of the disease. Psychological evaluation during long-term follow-up improved QoL scores, which reached the same levels noted in subjects with a history of thyroid surgery for benign thyroid pathology. Our data indicate that special attention should be paid to QoL in older DTC subjects and those with more severe staging on diagnosis.

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Understanding the Relationship Between Age and Thyroid Cancer

Cited by 111 publications

References 32 publications

Distinct chromatin signatures of DNA hypomethylation in aging and cancer

Distinct chromatin signatures of DNA hypomethylation in aging and cancer

The association between serum TSH concentration and thyroid cancer

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

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