2016
DOI: 10.1002/1873-3468.12415
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Understanding the regulation of vertebrate hematopoiesis and blood disorders – big lessons from a small fish

Abstract: Hematopoietic stem cells (HSCs) give rise to all differentiated blood cells. Understanding the mechanisms that regulate self-renewal and lineage specification of HSCs is key for developing treatments for many human diseases. Zebrafish have emerged as an excellent model for studying vertebrate hematopoiesis. This review will highlight the unique strengths of zebrafish and important findings that have emerged from studies of blood development and disorders using this system. We discuss recent advances in our und… Show more

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Cited by 35 publications
(27 citation statements)
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“…We do not intend here to provide detailed overview of non-human models, as this extensive topic has been reviewed recently by us and by others Kim et al, 2014;Ciau-Uitz et al, 2016;Kauts et al, 2016;Robertson et al, 2016;Crisan and Dzierzak, 2016). Owing to the high accessibility of model organisms for experimentation and the genetic variability and rarity of human embryonic material, the analysis of human haematopoietic development has lagged behind these wellestablished experimental models and for a long time was limited to immunohistological and in vitro studies.…”
Section: Introductionmentioning
confidence: 99%
“…We do not intend here to provide detailed overview of non-human models, as this extensive topic has been reviewed recently by us and by others Kim et al, 2014;Ciau-Uitz et al, 2016;Kauts et al, 2016;Robertson et al, 2016;Crisan and Dzierzak, 2016). Owing to the high accessibility of model organisms for experimentation and the genetic variability and rarity of human embryonic material, the analysis of human haematopoietic development has lagged behind these wellestablished experimental models and for a long time was limited to immunohistological and in vitro studies.…”
Section: Introductionmentioning
confidence: 99%
“…As UFM1 has been shown to be crucial for hematopoiesis (Tatsumi et al, 2011;Zhang et al, 2015;Cai et al, 2015), we then studied the relevance of MRE11 UFMylation in vivo in a zebrafish model using the unique advantages of zebrafish for genetic analysis of hematopoiesis. As in mammals, zebrafish hematopoiesis occurs in two waves: the primitive wave generates a transient population of blood cells, while the second wave generates hematopoietic stem cells (HSCs) by around 30 hours post-fertilization (Robertson et al, 2016). Genetic inactivation of either ufm1, ufl1 or mre11a with CRISPR-Cas9 ( Fig.…”
Section: Ufm1 Pathway Is Essential To Prevent Telomere Instability Anmentioning
confidence: 99%
“…4.1a). The earliest hematopoietic cells emerge during the primitive wave, which gives rise to mostly erythroid and myeloid cells arising from the lateral mesoderm during the first 24 h post fertilization (hpf) (equivalent to blood formation in the mammalian yolk sac) (reviewed in Robertson et al (2016)). The final wave gives rise to definitive HSCs that persist into adulthood to maintain hematopoiesis throughout the organism’s life.…”
Section: 1 Introductionmentioning
confidence: 99%