Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Rangon, Claire-Marie; Niezgoda, Adam

doi:10.3390/bioengineering9080352

Cited by 8 publications

(5 citation statements)

References 117 publications

(129 reference statements)

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“…As results, a significant drop in HF power related to SARS-CoV-2 infection was consis-tently observed [49,55,59,61]. This may be understood in the context of vagal invasion by SARS-CoV-2 and the important role of the nerve system in neuroimmunometabolism [67]. A potential association with the significant reduction in HF power observed in patients with long COVID can also be assumed [68], as the development of postural orthostatic syndrome after COVID-19 involves mechanisms such as increased sympathetic activity and decreased parasympathetic activity due to SARS-CoV-2 infection [69].…”

Section: Clinical Interpretationmentioning

confidence: 78%

The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

Kwon

2023

IJERPH

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Autonomic nervous system (ANS) dysfunction can arise after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and heart rate variability (HRV) tests can assess its integrity. This review investigated the relationship between the impact of SARS-CoV-2 infection on HRV parameters. Comprehensive searches were conducted in four electronic databases. Observational studies with a control group reporting the direct impact of SARS-CoV-2 infection on the HRV parameters in July 2022 were included. A total of 17 observational studies were included in this review. The square root of the mean squared differences of successive NN intervals (RMSSD) was the most frequently investigated. Some studies found that decreases in RMSSD and high frequency (HF) power were associated with SARS-CoV-2 infection or the poor prognosis of COVID-19. Also, decreases in RMSSD and increases in the normalized unit of HF power were related to death in critically ill COVID-19 patients. The findings showed that SARS-CoV-2 infection, and the severity and prognosis of COVID-19, are likely to be reflected in some HRV-related parameters. However, the considerable heterogeneity of the included studies was highlighted. The methodological quality of the included observational studies was not optimal. The findings suggest rigorous and accurate measurements of HRV parameters are highly needed on this topic.

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Section: Clinical Interpretationmentioning

confidence: 78%

The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

Kwon

2023

IJERPH

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“…This pathway can also be activated via non-invasive Vagus Nerve Stimulation (nVNS) [ 15 ], which could turn out to be a true game changer not only in etiologic rehabilitation [ 16 ] but also in symptomatic rehabilitation, notably acting on motor rehabilitation [ 17 ] and pain [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Case Report: The Rehabilitation of a Patient with Acute Transverse Myelitis after COVID-19 Vaccination

Niebrzydowski,

Kusiak-Kaczmarek,

Tomaszewski

et al. 2024

Clinics and Practice

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We report the case of a 55-year-old man with multi-symptomatic transverse myelitis after vaccination against coronavirus disease 2019 (COVID-19). The patient was diagnosed based on the course of the disease and the results of imaging and laboratory tests. We excluded other most probable causes of the disease. The quick start of diagnosis allowed for early treatment with intravenous steroids and then plasmapheresis and the implementation of modern rehabilitation methods using biofeedback platforms, among others, and an exoskeleton. The patient returned to work, but the rehabilitation process continues to this day due to persistent symptoms that impair the patient’s quality of life.

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“…Vagus nerve stimulation (VNS) has been found to promote motor activity by increasing neuroplasticity and facilitating cortical reorganization and neurogenesis [31,32]. Therefore, it seems reasonable to expand the knowledge of cranial nerve stimulation in Beckwith-Wiedemann syndrome, including stimulation of the trigeminal nerve as well as in the future of other nerves, including the vagus nerve, which can improve not only articulatory performance but also hyperinsulinemic hypoglycemia, breathing difficulties, and psychological issues in later life [33,34].…”

Section: Discussionmentioning

confidence: 99%

Application of Original Therapy for Stimulation of Oral Areas Innervated by the Trigeminal Nerve in a Child with Beckwith–Wiedemann Syndrome

et al. 2023

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About 90% of children diagnosed with classic BWS have macroglossia, and 40% of them are submitted to surgical tongue reduction. The purpose of our article is to present a case study of a 5-month-old child with BWS who was treated with an original therapy for stimulation of oral areas innervated by the trigeminal nerve. The therapy included stimulation of the upper and lower lip and muscles of the floor of the mouth. The treatment was provided by a therapist once a week. In addition, the child was stimulated every day at home by his mother. After 3 months, a significant improvement in oral alignment and function was achieved. Preliminary observations of therapy application for stimulation regions innervated by the trigeminal nerve in children with Beckwith–Wiedemann syndrome seem promising. The original therapy for stimulation of oral areas innervated by the trigeminal nerve is a good alternative to existing methods of surgical tongue reduction in children with BWS and macroglossia.

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Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Cited by 8 publications

References 117 publications

The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

Case Report: The Rehabilitation of a Patient with Acute Transverse Myelitis after COVID-19 Vaccination

Application of Original Therapy for Stimulation of Oral Areas Innervated by the Trigeminal Nerve in a Child with Beckwith–Wiedemann Syndrome

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