Understanding the phase and solvation behavior of fluorinated ionic liquids

Ferreira, Margarida L.; Vieira, Nicole S. M.; Castro, Paulo Francisco de; Vega, Lourdes F.; Araújo, João M. M.; Pereiro, Ana B.

doi:10.1016/j.molliq.2022.119285

Cited by 10 publications

(9 citation statements)

References 119 publications

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“…To study the influence of IFN-α 2b on the aggregates of FILs, two FILs were selected: [C 2 C 1 Im][C 4 F 9 SO 3 ] and [N 1112(OH ][C 4 F 9 SO 3 ]. These FILs have outstanding surface-active properties, full miscibility in water, and negligible toxicity [ 31 , 32 , 38 ]. Both FILs can form different aggregates that were identified by the determination of distinct CACs in water [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…The use of ILs as DDSs has been under investigation due to their capacity to stabilize and enhance the solubilization of macromolecules such as proteins [ 27 , 28 ], especially the surface-active ionic liquids (SAILs) [ 29 , 30 ]. Fluorinated ionic liquids (FILs) are a family of SAILs and have shown promising results in the biopharmaceutical field [ 31 , 32 ]. These compounds are characterized by the introduction of perfluoroalkyl chains with equal or more than four carbon atoms in the cation and/or anion.…”

Section: Introductionmentioning

confidence: 99%

“…These compounds are characterized by the introduction of perfluoroalkyl chains with equal or more than four carbon atoms in the cation and/or anion. This structural feature can promote the formation of three nano-segregated domains (one polar and two non-polar: hydrogenous and fluorous), which grant improved properties to FILs [ 31 , 32 , 33 , 34 , 35 , 36 ]. They are mainly characterized by impressive surfactant power, chemical and biological inertness, low surface tension, negligible vapour pressure, tuneability, and high thermal stability, along with other excellent properties that are common in the conventional ILs and perfluoroalkyl compounds, such as high solubility of gases [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…This structural feature can promote the formation of three nano-segregated domains (one polar and two non-polar: hydrogenous and fluorous), which grant improved properties to FILs [ 31 , 32 , 33 , 34 , 35 , 36 ]. They are mainly characterized by impressive surfactant power, chemical and biological inertness, low surface tension, negligible vapour pressure, tuneability, and high thermal stability, along with other excellent properties that are common in the conventional ILs and perfluoroalkyl compounds, such as high solubility of gases [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. FILs constituted by perfluoroalkyl anions with only four carbon atoms have shown enhanced self-aggregation behaviour that aids the formation of self-assembled structures in aqueous solutions [ 31 , 32 , 38 ], which combined with the low surface tension [ 31 ] make FILs highly surface-active compounds.…”

Section: Introductionmentioning

confidence: 99%

“…This superior surfactant behaviour allows those FILs to be completely miscible in aqueous solutions [ 38 ]. Moreover, FILs can be customized to have negligible cytotoxicity in four different human cell lines [ 31 , 32 , 39 , 40 ], high acceptance of red blood lysis [ 32 ], and insignificant ecotoxicity to several aquatic species and bacteria [ 31 , 32 ]. These properties have been key to considering the use of FILs in the biological field, especially in the formulation of DDSs for therapeutic proteins.…”

Section: Introductionmentioning

confidence: 99%

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Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

et al. 2022

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Interferon-alpha 2b (IFN-α 2b) is a therapeutic protein used for the treatment of cancer, viral infections, and auto-immune diseases. Its application is hindered by a low bioavailability and instability in the bloodstream, and the search for new strategies for a target delivery and stabilization of IFN-α 2b to improve its therapeutic efficacy is crucial. Fluorinated ionic liquids (FILs) are promising biomaterials that: (i) can form self-assembled structures; (ii) have complete miscibility in water; and (iii) can be designed to have reduced toxicity. The influence of IFN-α 2b in the aggregation behaviour of FILs and the interactions between them were investigated through conductivity and surface tension measurements, and using electron microscopic and spectroscopy techniques to study FILs feasibility as an interferon-alpha 2b delivery system. The results show that the presence of IFN-α 2b influences the aggregation behaviour of FILs and that strong interaction between the two compounds occurs. The protein might not be fully encapsulated by FILs. However, the FIL can be tailored in the future to carry IFN-α 2b by the formation of a conjugate, which prevents the aggregation of this protein. This work constitutes a first step toward the design and development of FIL-based IFN-α 2b delivery systems.

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