2022
DOI: 10.3390/pharmaceutics14081635
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Understanding the pH Dependence of Supersaturation State—A Case Study of Telmisartan

Abstract: Creating supersaturating drug delivery systems to overcome the poor aqueous solubility of active ingredients became a frequent choice for formulation scientists. Supersaturation as a solution phenomenon is, however, still challenging to understand, and therefore many recent publications focus on this topic. This work aimed to investigate and better understand the pH dependence of supersaturation of telmisartan (TEL) at a molecular level and find a connection between the physicochemical properties of the active… Show more

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Cited by 2 publications
(3 citation statements)
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“…In the case of the nanonized samples, the amorphous character is also observable at the end of the measurements in all media; however, the characteristic peaks are appearing on the diffractogram but with low intensity. Therefore, the higher equilibrium solubility results can be attributable to the combined effect of the particle size reduction and the amorphous character [ 28 , 29 ].…”
Section: Resultsmentioning
confidence: 99%
“…In the case of the nanonized samples, the amorphous character is also observable at the end of the measurements in all media; however, the characteristic peaks are appearing on the diffractogram but with low intensity. Therefore, the higher equilibrium solubility results can be attributable to the combined effect of the particle size reduction and the amorphous character [ 28 , 29 ].…”
Section: Resultsmentioning
confidence: 99%
“…The pH– S pH LLPS profiles of CPH, DCF, and PRF followed the HH equation, whereas that of PAP did not (Figure C). Previously, the pH–crystalline solubility profile of PAP was reported to deviate from the HH equation owing to the formation of cationic aggregates. , Therefore, the formation of cationic aggregates would also be the reason for the deviation of the pH– S pH LLPS profile from the HH equation . Fuguet et al used mass spectrometry to confirm that CPH formed aggregates in the pH–crystalline solubility profile .…”
Section: Discussionmentioning
confidence: 99%
“…23,38 Therefore, the formation of cationic aggregates would also be the reason for the deviation of the pH−S pH LLPS profile from the HH equation. 39 Fuguet et al used mass spectrometry to confirm that CPH formed aggregates in the pH−crystalline solubility profile. 24 However, the pH−S pH LLPS profile of CPH followed the HH equation.…”
Section: Llpsmentioning
confidence: 99%