Understanding the Pathological Stages of Peyronie’s Disease and Treatment Options at Each Stage

Abstract

Peyronie's disease is a treatable disease. Understanding its pathogenesis is the cornerstone for establishing a treatment plan. When the disease is in the early stage, characterized by presence of pain and tenderness, the treatment is directed against the inflammation process. This can be achieved mainly by oral medications. On the other side, when the disease progress to formation of plaque, the treatment is mainly by intralesional injections, shockwave therapy, and surgery.Methodology: I reviewed articles published in English and indexed in the PubMed®, Embase® and Google Scholar™ databases, and consulted textbooks. Key search terms used were ''Peyronie's disease, Erectile dysfunction, Hourglass deformity, Citoject, Intralesional treatment''. I created a synopsis of relevant articles, including original research studies and reviews. Conclusion:Understanding the pathological background for Peyronie's disease is essential to determine the pertinent treatment option according to patient clinical presentation.