Understanding the neuropsychiatric consequences associated with significant traumatic brain injury

Bhalerao, Shree; Geurtjens, Carly; Thomas, Garry R.; Kitamura, Christopher; Zhou, Carrol; Marlborough, Michelle

doi:10.3109/02699052.2013.793396

Cited by 58 publications

(34 citation statements)

References 52 publications

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“…Injury-induced sleep disturbances also potentially affect the course of recovery [6,10] and hinder rehabilitation [11]. Chronic sleep disturbances not only compromise recovery, but can intensify co-morbidities including anxiety, depression, cognitive deficits and pain [11][12][13][14]. For these reasons, exploring animal models that recapitulate aspects of injury-induced sleep problems is timely.…”

Section: Introductionmentioning

confidence: 99%

Diffuse brain injury does not affect chronic sleep patterns in the mouse

et al. 2014

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Previously, it has been shown that the midline fluid percussion model used in this study immediately increased post-traumatic sleep. The current study extended the timeline of investigation to show that sleep disturbances extended into the first week post-injury, but did not develop into chronic sleep disturbances. However, the clinical prevalence of TBI-related sleep-wake disturbances warrants further experimental investigation.

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Section: Introductionmentioning

confidence: 99%

Diffuse brain injury does not affect chronic sleep patterns in the mouse

et al. 2014

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“…[16][17][18] Study design has been described previously. 16,17 In brief, inclusion criteria were severe, non-penetrating, traumatic brain injury requiring neurointensive care, with acute Glasgow Coma Scale score of [3][4][5][6][7][8]19 in adult patients aged 18-65 years. Exclusion criteria were death or expected death within 3 weeks of injury.…”

Section: Methodsmentioning

confidence: 99%

“…A variety of terms have been used to describe these behavioural changes. [5][6][7][8][9] Descriptions in the literature pertaining to TBI include variations of "neurobehavioral symptoms", 5 "neuropsychatric consequences" 6 as well as standard definitions of psychiatric disorders (e.g. according to Diagnostic System Manual DSM 10 or International Classification of Disease ICD criteria), 11 applied to patients after traumatic brain injury.…”

Section: Introductionmentioning

confidence: 99%

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

et al. 2016

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Objective: To investigate the occurrence of behavioural problems in patients with severe traumatic brain injury during the first year after injury and potential associations with outcome. An additional post hoc objective was to analyse the frequency of behaviours with need for intervention from staff. Design and setting: In a prospective population based cohort study 114 patients with severe traumatic brain injury were assessed at three weeks, three months and one year after injury. Main measures: Assessments included clinical examination and standardised instruments. Agitation was assessed with the Agitated Behaviour Scale, the course of recovery by the Rancho Los Amigo Scale and outcome by Glasgow Outcome Scale Extended. Results: Agitation were most common at 3 weeks post injury and 28% (n=68) of the patients showed at least one agitated behaviour requiring intervention from staff. Presence of significant agitation at 3 weeks after injury was not associated with poor outcome. At 3 months agitation was present in 11% (n=90) and apathy in 26 out of 81 assessed patients. At 3 months agitation and apathy were associated with poor outcome at one year. Conclusions: Most agitated behaviours in the early phase are transient and are not associated with poor outcome. Agitation and apathy are uncommon at three months but when present are associated with poor outcome at one year after injury. In the early phase after a severe traumatic brain injury agitated behaviour in need of interventions from staff occur in a substantial proportion of patients.

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“…Among all patients sustaining head injury,~10% will develop an incidence of post-traumatic seizures [3]. Post-traumatic seizures (PTS) after TBI are often related to a major source of disability, which alter intracranial pressure, blood pressure and oxygen delivery to cerebral tissue [4,5]. These seizures are traditionally classified into early, occurring within 7 days of injury, or late, occurring after 7 days of injury [6].…”

Section: Introductionmentioning

confidence: 99%

The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis

Xu¹,

Shen²,

Shao

et al. 2016

Brain Injury

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Understanding the neuropsychiatric consequences associated with significant traumatic brain injury

Abstract: Neuropsychiatric sequelae are common following TBI. Several of these syndromes are amenable to treatment. Further investigations are required, however, to better understand the mechanistic aetiology of these conditions and the effectiveness of various therapeutic modalities.

Cited by 58 publications

References 52 publications

Diffuse brain injury does not affect chronic sleep patterns in the mouse

Diffuse brain injury does not affect chronic sleep patterns in the mouse

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis

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