Understanding the interactive effects of dietary leucine with isoleucine and valine in the modern commercial broiler

Kriseldi, R.; Silva, M.; Lee, J.; Adhikari, Roshan; C., Williams,; Corzo, A.

doi:10.1016/j.psj.2022.102140

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…High concentrations of BCAAs can stimulate muscle protein synthesis and promote muscle growth. Several studies have shown that adding leucine [ 29 , 30 , 31 ], isoleucine, and valine to the diet can improve muscle growth in organisms. Therefore, the degradation of valine, leucine, and isoleucine after amantadine exposure may have indicated that A. japonicus growth was inhibited.…”

Section: Discussionmentioning

confidence: 99%

Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics

Zhao

Chen

Tian

et al. 2023

Toxics

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Amantadine exposure can alter biological processes in sea cucumbers, which are an economically important seafood in China. In this study, amantadine toxicity in Apostichopus japonicus was analyzed by oxidative stress and histopathological methods. Quantitative tandem mass tag labeling was used to examine changes in protein contents and metabolic pathways in A. japonicus intestinal tissues after exposure to 100 µg/L amantadine for 96 h. Catalase activity significantly increased from days 1 to 3 of exposure, but it decreased on day 4. Superoxide dismutase and glutathione activities were inhibited throughout the exposure period. Malondialdehyde contents increased on days 1 and 4 but decreased on days 2 and 3. Proteomics analysis revealed 111 differentially expressed proteins in the intestines of A. japonicus after amantadine exposure compared with the control group. An analysis of the involved metabolic pathways showed that the glycolytic and glycogenic pathways may have increased energy production and conversion in A. japonicus after amantadine exposure. The NF-κB, TNF, and IL-17 pathways were likely induced by amantadine exposure, thereby activating NF-κB and triggering intestinal inflammation and apoptosis. Amino acid metabolism analysis showed that the leucine and isoleucine degradation pathways and the phenylalanine metabolic pathway inhibited protein synthesis and growth in A. japonicus. This study investigated the regulatory response mechanisms in A. japonicus intestinal tissues after exposure to amantadine, providing a theoretical basis for further research on amantadine toxicity.

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Section: Discussionmentioning

confidence: 99%

Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics

Zhao

Chen

Tian

et al. 2023

Toxics

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“…Dietary amino acids are best known as building blocks for proteins and substrates for synthesis of small molecular substances and tissue growth, and have profound biological importance, crucial for whole body homeostasis ( Eugenio et al, 2022 ). Among them, the branched-chain amino acids ( BCAA ), including isoleucine ( Ile ), leucine, and valine, in addition to precursor function, also play important roles in control of energy homeostasis, nutritional metabolism, immunity, and intestinal health in animals ( Zhang et al, 2017 ; Nie et al, 2018 ; Brown et al, 2022 , Kriseldi et al, 2022 ). It has been noted that the requirement for BCAA is influenced by the diet type, breed, and age of the birds.…”

Section: Introductionmentioning

confidence: 99%

Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens

Ruan,

Fan,

Zhang

et al. 2023

Poultry Science

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Metabolomic Profiling, Volatile Fatty Acids, and Greenhouse Gas Emissions of Beef Cattle Infused with Different Essential Oil Blends

Okedoyin,

Alabi,

Anotaenwere

et al. 2024

Ruminants

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Essential oils are natural feed additives that improve animal health and enhance their performance. This study investigated the effects of the rumen infusion of five essential oil blends (EOBs) on greenhouse gas (GHG) emissions, rumen fermentation parameters, and rumen metabolome and metabolic pathways in Black Angus cows. Using a 6 × 6 Latin Square experimental design, a 90-day study was conducted with six cattle. A daily dosage of 4 mL of EOBs was administered during each infusion. Volcano plot analyses between the control (CON) and each of the EOBs (EOB1, EOB2, EOB3, EOB4, and EOB5) revealed several differentially abundant (p ≤ 0.05; absolute fold change ≥1.5) metabolites. The EOB5 treatment exhibited the most significant impact, with 26 differentially abundant metabolites, including elevated valine and reduced gallic acid. Volatile fatty acids (VFAs), including valerate, isobutyrate, and isovalerate, were significantly increased (p < 0.05). GHG emissions were not significantly affected, but a numerical decrease was observed in the animals infused with the EOB5 treatment. Ammonia nitrogen concentrations remained within the suitable range for rumen microbes’ growth, indicating a normal internal environment for microbial crude protein synthesis. In conclusion, the study has demonstrated that the direct infusion of EOBs significantly improved the generation of VFAs and impacted the energy production, protein synthesis, and microbial activity of the animals.

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Understanding the interactive effects of dietary leucine with isoleucine and valine in the modern commercial broiler

Cited by 3 publications

References 27 publications

Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics

Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics

Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens

Metabolomic Profiling, Volatile Fatty Acids, and Greenhouse Gas Emissions of Beef Cattle Infused with Different Essential Oil Blends

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