Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of β-TCP ceramics

Banerjee, Soumik; Tarafder, Solaiman; Davies, Neal M.; Bandyopadhyay, Amit; Bose, Susmita

doi:10.1016/j.actbio.2010.05.012

Cited by 154 publications

(140 citation statements)

References 32 publications

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“…Among other CaPs, the resorbable property of tricalcium phosphate (TCP) makes it an excellent candidate to be applicable as a biodegradable bone substitute for many orthopedic and dental applications. 8,12,13 Biodegradable bone substitutes eventually degrade and replaced by new bone.…”

Section: Introductionmentioning

confidence: 99%

SrO‐ and MgO‐doped microwave sintered 3D printed tricalcium phosphate scaffolds: Mechanical properties and in vivo osteogenesis in a rabbit model

et al. 2014

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The presence of interconnected macro pores allows guided tissue regeneration in tissue engineering scaffolds. However, highly porous scaffolds suffer from having poor mechanical strength. Previously, we showed that microwave sintering could successfully be used to improve mechanical strength of macro porous tricalcium phosphate (TCP) scaffolds. This study reports the presence of SrO and MgO as dopants in TCP scaffolds improves mechanical and in vivo biological performance. We have used direct three dimensional printing (3DP) technology for scaffold fabrication. These 3DP scaffolds possessed multiscale porosity, that is, 3D interconnected designed macro pores along with intrinsic micro pores. A significant increase in mechanical strength, between 37 and 41%, was achieved due to SrO and MgO doping in TCP as compared with pure TCP. Maximum compressive strengths of 9.38 ± 1.86 MPa and 12.01 ± 1.56 MPa were achieved by conventional and microwave sintering, respectively, for SrO‐MgO‐doped 3DP scaffolds with 500 μm designed pores. Histomorphological and histomorphometric analysis revealed a significantly higher osteoid, bone and haversian canal formation induced by the presence of SrO and MgO dopants in 3DP TCP as compared with pure TCP scaffolds when tested in rabbit femoral condyle defect model. Increased osteon and thus enhanced network of blood vessel formation, and osteocalcin expression were observed in the doped TCP scaffolds. Our results show that these 3DP SrO‐MgO‐doped TCP scaffolds have the potential for early wound healing through accelerated osteogenesis and vasculogenesis. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 679–690, 2015.

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Section: Introductionmentioning

confidence: 99%

SrO‐ and MgO‐doped microwave sintered 3D printed tricalcium phosphate scaffolds: Mechanical properties and in vivo osteogenesis in a rabbit model

et al. 2014

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“…Incorporation of Mg 2+ ions suppresses the β→α TCP phase transition and the bone metabolism improves, reducing cardiovascular diseases by promoting catalytic reactions and controlling biological functions [8]. Banerjee et al [12] demonstrated better cell attachment and proliferation for doped β-TCP in an in vitro cell-material interaction study and in an in vivo study as well. The authors reported that bone forms more quickly in doped samples than in control samples.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of 3CaO·P2O5-SiO2-MgO glass-ceramics with different crystallization degree

et al. 2013

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The CaO-P 2 O 5 -SiO 2 -MgO system presents several compounds used as biomaterials such as hydroxyapatite (HA), tricalcium phosphate (TCP) and TCP with magnesium substituting partial calcium (TCMP). The β-TCMP phase with whitlockite structure has interesting biological features and mechanical properties, meeting the requirements of a bioactive material for bone restoration. In this work, the production of Mg-doped TCP, β-TCMP, has been investigated by crystallization from a glass composed of 52.75 wt% 3CaO·P 2 O 5 , 30 wt% SiO 2 and 17.25 wt% MgO (i.e., 31.7 mol% CaO, 10.6 mol% P 2 O 5 , 26.6 mol% MgO and 31.1 mol% SiO 2 ) using heat treatments between 775 ℃ and 1100 ℃ for up to 8 h. The devitrification process of the glass has been accompanied by differential scanning calorimetry (DSC), high-resolution X-ray diffraction (HRXRD), relative density and bending strength measurements. The characterization by HRXRD and DSC revealed the occurrence of whitlockite soon after the bulk glass preparation, a transient non-cataloged silicate between 800 ℃ and 1100 ℃, and the formation of diopside in samples treated at 1100 ℃ as crystalline phases. The overall crystalline fraction varied from 26% to 70% depending on the heat treatments. Furthermore, contraction of the a-axis lattice parameter and expansion of the c-axis lattice parameter of the whitlockite structure have been observed during the heat treatments, which were attributed to the β-TCMP formation with the partial substitution of Ca 2+ by Mg 2+ . Relative densities near 99% and 97% for the glass and glass-ceramics respectively indicated a discrete reduction as a function of the devitrification treatment. Bending strengths of 70 MPa and 120 MPa were determined for the glass and glass-ceramic material crystallized at 975 ℃ for 4 h, respectively.

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“…However, the FAp and the b-TCP phases were observed at all annealing temperatures. Moreover, up to 900 C, the traces of the REPO 4 (where RE -Er 3+ , Yb 3+ ) were identied, but these extra phases…”

Section: Structural and Morphological Analysismentioning

confidence: 99%

“…4 Nevertheless, there is a remaining interest in improvement of their properties in order to achieve a better biological response. One of the methods consists of embedding some additives into the apatite structure, another involves the use of biphasic calcium phosphates containing both compounds -for instance HAp and b-TCP.…”

Section: Introductionmentioning

confidence: 99%

Preparation of up-converting nano-biphasic calcium phosphate

et al. 2017

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The nano-biphasic calcium phosphate co-doped with 1 mol% Er 3+ and 5 mol% Yb 3+ ions was prepared using Pechini's technique. The preparation of the biphasic calcium phosphate showed the removal of fluorine ions from the matrix. The structural properties and morphology of the particles were studied by means of XRD (X-ray powder diffraction), TEM (Transmission Electron Microscopy), and SEM (Scanning nano-biphasic calcium phosphate were investigated in detail using emission spectra, power dependence and emission kinetics. This material demonstrated intense green up-conversion depending on laser power. Additionally, the luminescence lifetimes for Er 3+ ions were calculated from the measured decays.Power dependence of the green and red emissions was found to result from a temperature increase of nano-biphasic calcium phosphate that opens potential applications in theranostics.

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Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of β-TCP ceramics

Cited by 154 publications

References 32 publications

SrO‐ and MgO‐doped microwave sintered 3D printed tricalcium phosphate scaffolds: Mechanical properties and in vivo osteogenesis in a rabbit model

SrO‐ and MgO‐doped microwave sintered 3D printed tricalcium phosphate scaffolds: Mechanical properties and in vivo osteogenesis in a rabbit model

Development and characterization of 3CaO·P2O5-SiO2-MgO glass-ceramics with different crystallization degree

Preparation of up-converting nano-biphasic calcium phosphate

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