Understanding the influence of HEPES buffer concentration on the biodegradation of pure magnesium: An electrochemical study

Kannan, M. Bobby; Khakbaz, Hadis; Yamamoto, Akiko

doi:10.1016/j.matchemphys.2017.05.024

Cited by 21 publications

(10 citation statements)

References 38 publications

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“…Under the same conditions, HEPES increases the corrosion rate of pure Mg by a factor of up to four times compared with NaHCO 3 buffering alone not only in simple salt solutions but also in EBSS and DMEM [ 7 , 25 , [34] , [35] , [36] ]. For WZ21 alloy, this factor increased to approximately 60 in SBF buffered with HEPES (100 mmol/L) compared with that buffered with CO 2 /NaHCO 3 [ 18 ].…”

Section: Simulated or Not? The Question Of Appropriate Conditionsmentioning

confidence: 99%

Magnesium degradation under physiological conditions – Best practice

González

Hou

Nidadavolu

et al. 2018

Bioactive Materials

196

130

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This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation. Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes, realistic and predictive in vitro setups are needed. Due to the complexity of these systems, the review gives an overview about technical measures, defines some caveats and can be used as a guideline for the establishment of harmonized laboratory approaches.

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Section: Simulated or Not? The Question Of Appropriate Conditionsmentioning

confidence: 99%

Magnesium degradation under physiological conditions – Best practice

González

Hou

Nidadavolu

et al. 2018

Bioactive Materials

196

130

View full text Add to dashboard Cite

show abstract

“…The addition of HEPES can increase the ionic strength of the solution, resulting in the accelerated dissolution of pure zinc. [ 51 ] The sustained stability of the pH value at the first 15 days can be attributed to the large amount of HCO 3 − in DMEM. In addition, glucose has a good corrosion inhibition efficiency and shows both the physical and chemical adsorptions of an inhibitor molecule on a metal surface.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the in vitro corrosion behavior of biodegradable pure Zn in SBF, 0.9% NaCl, and DMEM

Zhu

Guo

Yang

et al. 2021

Materials & Corrosion

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Zn‐based alloys are considered to be the new biodegradable implant materials due to their suitable degradation rate and good biocompatibility. The biocorrosion behavior of pure Zn in 0.9% NaCl, simulated body fluid, and Dulbecco's modified Eagle's medium (DMEM) was investigated by electrochemical and immersion tests. These tests revealed that pure Zn has the lowest corrosion rate in DMEM and the highest in 0.9% NaCl. Aggressive Cl− has an important effect on the corrosion process. Buffering agents, amino acids, and glucose have a close connection with corrosion resistance. Among the three solutions, DMEM with a similar ion concentration and necessary nutriments is recommended as the more suitable choice for estimating biodegradable alloys' in vitro degradation.

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“…NaHCO 3 /CO 2 buffer, 4-(2-hydroxyethyl)-1piperazineethanesulfonic acid (HEPES), and Tris-HCl (Tris Hydrochloride) are the most frequently used buffers for in vitro studies of Mg [37,84,93]. HEPES buffer increases Mg corrosion by a factor of up to four times compared to NaHCO 3 buffering alone in DMEM, EBSS, and simple salt solutions under the same conditions [94]. HEPES in testing solutions affects the nucleation process and reduces the formation of carbonate and phosphate in the degradation layer; in this way, the protective layer on Mg is destabilized, a less dense degradation layer is produced, and the progressive diffusion of aggressive ions is allowed [95,96].…”

Section: Mg Corrosion In Simulated Body Environmentsmentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

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In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.

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Understanding the influence of HEPES buffer concentration on the biodegradation of pure magnesium: An electrochemical study

Cited by 21 publications

References 38 publications

Magnesium degradation under physiological conditions – Best practice

Magnesium degradation under physiological conditions – Best practice

Comparison of the in vitro corrosion behavior of biodegradable pure Zn in SBF, 0.9% NaCl, and DMEM

Biodegradable Magnesium Biomaterials—Road to the Clinic

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