2018
DOI: 10.1016/j.meegid.2018.03.003
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Understanding the HPV integration and its progression to cervical cancer

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Cited by 119 publications
(117 citation statements)
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“…The HPV16 physical state is in episomal, integrated, and mixed forms in cervical lesions. The integration of HPV DNA can lead to a series of host responses, dysregulated expression of E6 and E7 , disrupted tumor suppressor genes and increased genetic instability …”
Section: Introductionmentioning
confidence: 99%
“…The HPV16 physical state is in episomal, integrated, and mixed forms in cervical lesions. The integration of HPV DNA can lead to a series of host responses, dysregulated expression of E6 and E7 , disrupted tumor suppressor genes and increased genetic instability …”
Section: Introductionmentioning
confidence: 99%
“…Although persistent infection with HPV 16/18 is regarded as the most important cofactor for CC progression [2,3], it is insu cient on its own. Emerging evidence has indicated that the TME is a critical contributor to cancer progression [6][7][8][9][10].…”
Section: Discussionmentioning
confidence: 99%
“…HPVs persistent infection is the causative cause of cervical cancer . Some of the hrHPV persistent infection will be followed by viral DNA integration with human genome, resulting in over expression of two viral oncogene E6 and E7 . These oncoproteins bind to the tumor suppressor genes p53 and the retinoblastoma protein (pRB), destroy their function, leading to dysplasia and invasive cancer .…”
Section: Discussionmentioning
confidence: 99%
“…[32][33][34][35] Some of the hrHPV persistent infection will be followed by viral DNA integration with human genome, resulting in over expression of two viral oncogene E6 and E7. [36][37][38][39][40] These oncoproteins bind to the tumor suppressor genes p53 and the retinoblastoma protein (pRB), destroy their function, leading to dysplasia and invasive cancer. [41][42][43] Therefore, the inhibition of E6 and E7 expression will stop or regress the development of high-grade CIN and thus reduces invasive cancer.…”
Section: Discussionmentioning
confidence: 99%