Understanding the Effect of a Solvent on the Crystal Habit

Stoica, Cristina; Verwer, P.; Meekes, Hugo; Hoof, P.J.C.M. van; Kaspersen, Frans M.; Vlieg, E.

doi:10.1021/cg0342314

Cited by 124 publications

(138 citation statements)

References 8 publications

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“…Thus, it is reasonable to speculate that the observed differences in the relative intensities of the peaks in the diffractograms of the ASP-II and ASP-III crystals in comparison to the ASP-I crystal could be attributed to the crystal habit or crystal size modification (23,24). In addition, this type of diversity observed in X-ray diffractograms by various other research groups have also been related either to the interaction between the solvent and the growing crystal surface or to the presence of solvent/non-solvent in the solute lattice (25,26). The DSC thermograms of unprocessed aspirin (ASP-I) crystals, and ASP crystals generated with DEE (ASP-II) or with DCM (ASP-III) by the modified diffusion method are shown in Fig.…”

Section: Resultsmentioning

confidence: 94%

“…In the present study, it is observed that using of different non-solvents in the same crystallization process yielded different crystal habits. These differences in the crystal habit could be attributed to the non-solvent-surface-solvent interactions which lead to relative growth of the surfaces in different directions to produce a specific shape (25,26).…”

Section: Resultsmentioning

confidence: 99%

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Studies on Aspirin Crystals Generated by a Modified Vapor Diffusion Method

et al. 2015

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Abstract. The objectives of the current investigation were (1) to study the influence of selected two different non-solvents (diethylether and dichloromethane) on the drug crystal formation of a model drug, aspirin (ASP-I) by the modified vapor diffusion method and (2) to characterize and compare the generated crystals (ASP-II and ASP-III) using different analytical techniques with that of unprocessed ASP-I. When compared to the classical vapor diffusion method which consumes about 15 days to generate drug crystals, the modified method needs only 12 h to get the same. Fourier transform-infrared spectroscopy (FT-IR) reveals that the internal structures of ASP-II and ASP-III crystals were identical when compared with ASP-I. Although the drug crystals showed a close similarity in X-ray diffraction patterns, the difference in the relative intensities of some of the diffraction peaks (especially at 2θ values of around 7.7 and 15.5) could be attributed to the crystal habit or crystal size modification. Similarly, the differential scanning calorimetry (DSC) study speculates that only the crystal habit modifications might occur but without involving any change in internal structure of the generated drug polymorphic form I. This is further substantiated from the scanning electron microscopy (SEM) pictures that indicated the formation of platy shape for the ASP-II crystals and needle shape for the ASP-III crystals. In addition, the observed slow dissolution of ASP crystals should indicate polymorph form I formation. Thus, the modified vapor diffusion method could routinely be used to screen and legally secure all possible forms of other drug entities too.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Studies on Aspirin Crystals Generated by a Modified Vapor Diffusion Method

et al. 2015

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“…The interaction of the solvent at the different crystalsolution interfaces may lead to altered roundness of growing crystal faces and/or edges, changes in crystal growth kinetics, and enhancement or inhibition of crystal growth at certain faces (Figure 7), thereby changing the crystal habit (Stoica et al, 2004;Tiwary, 2006). …”

Section: Solventmentioning

confidence: 99%

Recrystallization of Active Pharmaceutical Ingredients

Stieger¹,

Liebenberg²

2012

Crystallization - Science and Technology

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“…The growth interface of KDP is still beyond the reach of current methods, but for a limited number of systems involving less components, encouraging results have been obtained. 6,[39][40][41] These realistic calculations are very costly and the system size has to be quite small. Nevertheless, in this area a genuine contact between experiment and modelling is emerging.…”

Section: Closing the Gap?mentioning

confidence: 99%