Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect
Conghua Lu,
Ziyuan Gao,
Di Wu
et al.
Abstract:BackgroundThe dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in the therapeutic trajectory of non-small cell lung cancer (NSCLC). Understanding the functional dynamics and resistance mechanisms of TKIs is essential for advancing the treatment of NSCLC.MethodsThis study assessed the effects of short-term and long-term TKI treatments on the TME in NSCLC, particularly targeting epidermal growth factor receptor (EGFR) and anaplastic lymp… Show more
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