Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife

Bangma, Jacqueline T.; Guillette, Theresa C.; Bommarito, Paige A.; Ng, Carla A.; Reiner, Jessica L.; Lindstrom, Andrew B.; Strynar, Mark J.

doi:10.1016/j.envint.2021.107037

Cited by 39 publications

(42 citation statements)

References 139 publications

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“…Exposure to PFAS in combination with other xenobiotics, or particular environmental conditions, has been shown to have differential impacts on xenobiotic metabolism and distribution to tissues throughout the body ( Wang F. et al, 2011 ; Li Y. et al, 2017 ; Vidal et al, 2019 ; Bangma et al, 2022 ). A study conducted by Wang F. et al (2011) demonstrated that co-exposure to PFOS and Pentabromodiphenyl ether (BDE-47), a brominated flame retardant known to cause developmental neurotoxicity, caused decreased serum and brain concentrations of both chemicals compared to exposure to each chemical individually, in Wistar rat dams and pups when dams were exposed from GD 1 to PND 14.…”

Section: Neurotoxic Effects Of Co-exposures and Mixtures Of Pfasmentioning

confidence: 99%

“…Distribution of PFAS throughout the body can also be impacted by abiotic factors, including salinity and temperature, which may alter the levels of proteins that bind PFAS ( Bangma et al, 2022 ). For example, Vidal et al (2019) found that in a 28-day dietary exposure experiment in adult rainbow trout, concentrations of PFOS and PFHxS in the blood, liver, and brain increased with increased water temperature, as did the brain to blood ratio for PFOS.…”

Section: Neurotoxic Effects Of Co-exposures and Mixtures Of Pfasmentioning

confidence: 99%

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A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

et al. 2022

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Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that are chemically stable, resistant to degradation, and persistent in terrestrial and aquatic environments. Widespread use of PFAS in industrial processing and manufacturing over the last 70 years has led to global contamination of built and natural environments. The brain is a lipid rich and highly vascularized organ composed of long-lived neurons and glial cells that are especially vulnerable to the impacts of persistent and lipophilic toxicants. Generally, PFAS partition to protein-rich tissues of the body, primarily the liver and blood, but are also detected in the brains of humans, wildlife, and laboratory animals. Here we review factors impacting the absorption, distribution, and accumulation of PFAS in the brain, and currently available evidence for neurotoxic impacts defined by disruption of neurochemical, neurophysiological, and behavioral endpoints. Emphasis is placed on the neurotoxic potential of exposures during critical periods of development and in sensitive populations, and factors that may exacerbate neurotoxicity of PFAS. While limitations and inconsistencies across studies exist, the available body of evidence suggests that the neurobehavioral impacts of long-chain PFAS exposures during development are more pronounced than impacts resulting from exposure during adulthood. There is a paucity of experimental studies evaluating neurobehavioral and molecular mechanisms of short-chain PFAS, and even greater data gaps in the analysis of neurotoxicity for PFAS outside of the perfluoroalkyl acids. Whereas most experimental studies were focused on acute and subchronic impacts resulting from high dose exposures to a single PFAS congener, more realistic exposures for humans and wildlife are mixtures exposures that are relatively chronic and low dose in nature. Our evaluation of the available human epidemiological, experimental, and wildlife data also indicates heightened accumulation of perfluoroalkyl acids in the brain after environmental exposure, in comparison to the experimental studies. These findings highlight the need for additional experimental analysis of neurodevelopmental impacts of environmentally relevant concentrations and complex mixtures of PFAS.

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Section: Neurotoxic Effects Of Co-exposures and Mixtures Of Pfasmentioning

confidence: 99%

Section: Neurotoxic Effects Of Co-exposures and Mixtures Of Pfasmentioning

confidence: 99%

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

et al. 2022

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“…Previous studies reported that folate could maintain or enhance the cytotoxicity activity of NK cells, , support Th1-mediated immune responses, and play important roles in antibody production and metabolism. − The mechanism of how folate interacts with PFAS on the immune system is currently unclear and needs further experimental exploration. There is some evidence that folate and PFAS are substrates for several shared carriers including those in the ATP-binding cassette (ABC) family − and the organic anion transporters (OAT) family. − It is possible that folate could interact with PFAS on these receptors and influence their downstream effects on the immune system. Besides, as an important methyl donor, folate plays a critical role in DNA synthesis and methylation.…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents

Zhang

Mustieles

Wang

et al. 2023

Environ. Sci. Technol.

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Per-and polyfluoroalkyl substances (PFAS) exposure has been associated with reduced antibody levels. Higher red blood cell (RBC) folate was previously associated with lower serum PFAS concentrations in adolescents. This study included 819 adolescents aged 12−19 years who had detectable rubella and measles antibody levels in serum from the U.S. National Health and Nutrition Examination Survey 2003−2004 and 2009−2010 cycles.We found inverse associations between serum PFOS and PFHxS and rubella antibodies, between PFOA and mumps antibodies, and between PFAS mixtures and rubella and mumps antibodies, only among adolescents with RBC folate concentrations <66th percentile (lower folate group) while not among adolescents with higher RBC folate levels (upper folate group). Specifically, per quartile increase in serum concentrations of the total PFAS mixture was associated with a 9.84% (95% CI: −15.57%, −3.74%) decrease in rubella antibody and an 8.79% (95% CI: −14.39%, −2.82%) decrease in the mumps antibody concentrations only in the lower folate group, while null associations were found for the upper folate group. If confirmed in mechanistic studies or prospective epidemiologic studies, these findings may have important implications for using folate as a mitigation measure against immunerelated PFAS effects.

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“…Only 6:2 diPAP was recovered effectively by PPT and EMR extraction methodologies with recoveries of 104 ± 9% and 96 ± 7% respectively, each with good agreement with the regression coefficient of the expected concentrations. The application of the internal standard (6:2 diPAP- 13 C 2 ) for the quantification of 6:2/8:2 diPAP, 8:2 diPAP and diSAmPAP is likely resulting in the reduced concentration of each of these compounds, as the internal standard response was significantly elevated.…”

Section: Effects Of Concentration On Recoverymentioning

confidence: 99%

“…The distribution of PFASs throughout body tissue in wildlife is species specific and can be impacted by environmental and physiological changes [13]. Monitoring blood and blood products is commonly employed as a reliable and accurate indicator for total PFAS body burden [14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation and validation of methodologies for the extraction of per- and polyfluoroalkyl substances (PFASs) in serum of birds and mammals

et al. 2022

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Advances in analytical techniques have allowed greater detection of environmental contaminants from small volumes of sample. Four methodologies were evaluated for the extraction of 53 per- and polyfluoroalkyl substances (PFASs) from eight classes in 200 µL of avian and mammal serum. Spiked serums at four concentrations (0, 0.5, 5.0 and 25 ng mL−1) were prepared by protein precipitation (PPT), enhanced matrix removal (EMR), weak anion exchange (WAX), and hydrophilic-lipophilic balance (HLB) solid-phase extraction cartridges. The extract from each methodology was analysed by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS), and concentrations were compared with known concentrations in the spiked media. EMR performed the best overall, with 40 of 53 compounds effectively recovered at 5 ng mL−1. Furthermore, EMR was effective overall at concentrations ranging from 0.5 to 25 ng mL−1 for 39 out of 53. Similarly, PPT was effective for 35 of 53 compounds at all spiked serum concentrations. There was a negative correlation between internal standard recovery for compounds with increasing octanol–water coefficients (Kow) for WAX (R = − 0.65, p = 0.0043) and HLB (R = − 0.62, p = 0.0077) extractions, indicating methanol may not be a suitable solvent for long-chain PFAS extraction from protein-rich tissues. EMR and PPT represent fast and effective methodologies for the extraction of PFASs from low volumes of serum which allows greater accuracy and precision that can be applied to future human and wildlife biomonitoring programmes.

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Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife

Cited by 39 publications

References 139 publications

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents

Evaluation and validation of methodologies for the extraction of per- and polyfluoroalkyl substances (PFASs) in serum of birds and mammals

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