In sustainable entrepreneurship, innovation emerges as a fundamental driver of transformative change, shaping businesses' efforts to prioritize societal well-being and environmental stewardship. This chapter explores the multifaceted impact of innovation on sustainable entrepreneurship, emphasizing its pivotal role in shaping business models, driving technological advancements, fostering collaboration, and embracing adaptive strategies. Through collaborative initiatives, open innovation platforms, and adaptive approaches, entrepreneurs navigate challenges such as financial constraints, market reluctance to change, and regulatory obstacles. By embracing innovation, businesses can unlock growth opportunities, driving progress toward a future where economic prosperity aligns harmoniously with social equity and environmental preservation. This chapter advocates for companies to embrace innovative approaches in navigating the sustainability landscape, calling for a culture of cooperation, experimentation, and resilience.