Understanding the complex pathogenesis of oral cancer: A comprehensive review

Georgaki, Maria; Theofilou, Vasileios Ionas; Pettas, Efstathios; Stoufi, Eleana; Younis, Rania H.; Kolokotronis, Alexandros; Sauk, John J.; Nikitakis, Nikolaos G.

doi:10.1016/j.oooo.2021.04.004

Cited by 21 publications

(12 citation statements)

References 134 publications

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“…Oral cancers, also known as head and neck cancers, are malignancies that often occur in the oral cavity, especially the tongue and the floor of the mouth, the oropharynx, and the esophagus [ 195 , 196 , 197 , 198 ]. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in the world [ 199 ].…”

Section: Exosomes In Non-ocular Diseasesmentioning

confidence: 99%

Salivary Exosomes in Health and Disease: Future Prospects in the Eye

Liu

Hefley

Escandon

et al. 2023

IJMS

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Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological tissues. Their impact on several diseases, such as neurodegenerative, autoimmune, and ocular diseases, have been reported, but not fully unraveled. The exosomes that are derived from saliva are less studied, but offer significant advantages over exosomes from other sources, due to their accessibility and ease of collection. Thus, their role in the pathophysiology of diseases is largely unknown. In the context of ocular diseases, salivary exosomes have been under-utilized, thus creating an enormous gap in the literature. The current review discusses the state of exosomes research on systemic and ocular diseases and highlights the role and potential of salivary exosomes as future ocular therapeutic vehicles.

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Section: Exosomes In Non-ocular Diseasesmentioning

confidence: 99%

Salivary Exosomes in Health and Disease: Future Prospects in the Eye

Liu

Hefley

Escandon

et al. 2023

IJMS

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“…The transition from normal oral epithelium to dysplasia and ultimately to OSCC ( Fig 1B ) is a multistep process and is multifactorial in its etiopathogenesis. Owing to this multifactorial process, studies have explored the interplay between tissue inflammation, immunity, and the tumor microenvironment on etiopathogenesis [ 27 ]. In the case of Candida the “initiator” scenario, infection of mucosal tissue generates epithelial barrier destruction activating type 17 immune responses [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Is Candida albicans an opportunistic oncogenic pathogen?

et al. 2022

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“…Genetic susceptibility plays an important role in driving the multistep process of oral carcinogenesis with a gradual transition from normal lining epithelium to hyperplastic, dysplastic, and finally malignant epithelial changes. Importantly, as oral oncogenesis is a multifactorial process, recent research has explored the interplay of inflammation, immunity, and the host microenvironment on etiopathogenesis 3 . Various environmental risk factors have been described to cause OED including tobacco and alcohol consumption and to a lesser degree Human Papillomavirus infection 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, as oral oncogenesis is a multifactorial process, recent research has explored the interplay of inflammation, immunity, and the host microenvironment on etiopathogenesis 3 . Various environmental risk factors have been described to cause OED including tobacco and alcohol consumption and to a lesser degree Human Papillomavirus infection 3,4 . Moreover, ambiguous risk factors for development of OED and OSCC include the oral microbiome; however, its exact contribution to oral carcinogenesis is still not well understood 5–7 .…”

Section: Introductionmentioning

confidence: 99%

“…3 Various environmental risk factors have been described to cause OED including tobacco and alcohol consumption and to a lesser degree Human Papillomavirus infection. 3,4 Moreover, ambiguous risk factors for development of OED and OSCC include the oral microbiome; however, its exact contribution to oral carcinogenesis is still not well understood. [5][6][7] What is even less clear, is the role that the newly described "oral mycobiome" plays in oral cancer development.…”

Section: Introductionmentioning

confidence: 99%

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The oral mycobiome: Oral epithelial dysplasia and oral squamous cell carcinoma

Theofilou

Alfaifi

Montelongo-Jauregui

et al. 2022

J Oral Pathology Medicine

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Fungi, a diverse group of eukaryotic organisms, play distinct roles in health and disease. Recent advances in the field of mycobiology have enabled the characterization of the "human mycobiome." The human mycobiome has extensively been studied in various disease models. However, to date, the role of the oral mycobiome in oral carcinogenesis has yet to be elucidated. Candida albicans, the most common oral colonizer, has been speculated to display tumorigenic effects; however, the literature lacks consistent documentation from mechanistic studies on whether oral mycobiota act as drivers, facilitators, or passive colonizers of oral premalignancy and cancer. This review article provides an overview of existing hypothesis-driven mechanistic models that outline the complex interplay between the oral mycobiome and oral epithelial dysplasia as well as their potential clinical implications.

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Understanding the complex pathogenesis of oral cancer: A comprehensive review

Cited by 21 publications

References 134 publications

Salivary Exosomes in Health and Disease: Future Prospects in the Eye

Salivary Exosomes in Health and Disease: Future Prospects in the Eye

Is Candida albicans an opportunistic oncogenic pathogen?

The oral mycobiome: Oral epithelial dysplasia and oral squamous cell carcinoma

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