Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Neufer, P. Darrell; Bamman, Marcas M.; Muoio, Deborah M.; Bouchard, Claude; Cooper, Dan M.; Goodpaster, Bret H.; Booth, Frank W.; Kohrt, Wendy M.; Gerszten, Robert E.; Mattson, Mark P.; Hepple, Russell T.; Kraus, William E.; Reid, Michael B.; Bodine, Sue C.; Jakicic, John M.; Fleg, Jerome L.; Williams, John; Joseph, Lyndon; Evans, Mary; Maruvada, Padma; Rodgers, Mary M.; Roary, Mary; Boyce, Amanda T.; Drugan, Jonelle K.; Koenig, James I.; Ingraham, Richard H.; Krotoski, Danuta; Garcı́a-Cazarı́n, Mary L.; McGowan, Joan A.; Laughlin, Maren R.

doi:10.1016/j.cmet.2015.05.011

Cited by 365 publications

(305 citation statements)

References 56 publications

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“…The advances of various "omics" approaches along with the application of com-putational and systems biology approaches to problems in exercise biology should facilitate future progress in this domain, but this will require the integration of data from multiple platforms and require large sample sizes, big data sets, and expertise in computational biology to resolve the complex biology associated with diverse exercise responses (Zierath and Wallberg-Henriksson 2015). Although the health-promoting benefits of exercise have been recognized for centuries, direct evidence linking such effects to specific health outcomes and understanding how these effects exert their benefits in different populations remains elusive and a challenge for future research (Neufer et al 2015). A major step toward this goal will be to identify the molecules that are altered in key organs/tissues in response to exercise training and how these responses differ between individuals (i.e., high versus low exercise responders).…”

Section: Concluding Remarks: Future Challenges-knowledge Translationmentioning

confidence: 99%

Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges

Perry

Hawley

2017

Cold Spring Harb Perspect Med

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We provide an overview of groundbreaking studies that laid the foundation for our current understanding of exercise-induced mitochondrial biogenesis and its contribution to human skeletal muscle fitness. We highlight the mechanisms by which skeletal muscle responds to the acute perturbations in cellular energy homeostasis evoked by a single bout of endurancebased exercise and the adaptations resulting from the repeated demands of exercise training that ultimately promote mitochondrial biogenesis through hormetic feedback loops. Despite intense research efforts to elucidate the cellular mechanisms underpinning mitochondrial biogenesis in skeletal muscle, translating this basic knowledge into improved metabolic health at the population level remains a future challenge. E xercise represents a major challenge to multiple whole-body homeostatic functions. In an effort to overcome this challenge, numerous responses take place at the cellular and systemic levels that operate to blunt the homeostatic threats generated by exercise-induced increases in muscle energy turnover and oxygen demand . The capacity of skeletal muscle to adapt to repeated bouts of activity such that physical capacity is enhanced is termed exercise training. When considering endurance-based exercise (e.g., sustained activities that are .10 min duration and performed at 60% -90% of maximal oxygen uptake [VO 2max ] including sprint-interval training), the goals of such exercise are to induce an array of physiological and metabolic adaptations that enable an individual to increase the rate of energy production from both aerobic pathways, maintain tighter metabolic control (i.e., match adenosine triphosphate (ATP) production with ATP hydrolysis), minimize cellular perturbations, increase efficiency of motion, and improve the capacity of the trained musculature to resist

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Section: Concluding Remarks: Future Challenges-knowledge Translationmentioning

confidence: 99%

Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges

Perry

Hawley

2017

Cold Spring Harb Perspect Med

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“…En oposición a los CAA, existen medidas más saludables y flexibles para el CPC, tales como la alimentación saludable y la práctica regular de ejercicio físico, las que con llevan una serie de beneficios fisiológicos, físicos y mentales (Eime, Young, Harvey, Charity y Payne, 2013;Neufer et al, 2015;Prichard y Tiggemann, 2005). No obstante, este tipo de medidas saludables suelen ser menos seleccionadas.…”

Section: Introductionunclassified

Body dissatisfaction and abnormal eating behaviors in a community sample of Chilean adults / Insatisfacción corporal y comportamientos alimentarios anómalos en una muestra comunitaria de adultos chilenos

Oda-Montecinos

García

Beyle

et al. 2018

Rev. Mex. Trast. Alim.

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The aims of this research were to estimate the percentage of body weight dissatisfaction in males and females Chilean adults, assessing its relationship with different sociodemographic, behavioral and psychological variables, and analyzing whether the presence of body weight dissatisfaction acts as a risk factor for some disordered eating behaviors. The 654 participants (436 women, 218 men; age range 18-64 years, mean body mass index [BMI] 25.49 kg/m 2 ) were evaluated with a battery of self-administered questionnaires. The percentage of body weight dissatisfaction in the whole sample was 45.9% and significantly higher in women than men. Significant differences were observed in the clinical scales that evaluated disordered eating in function of the BMI of the participants; in those scales females also showed higher scores than males. Comparing participants with and without body weight dissatisfaction, the first one showed more unhealthy eating behaviors. The results of this study show how body weight dissatisfaction can interact and influence healthy habits, such as a daily eating behaviors and physical exercise. Keywords: Body weight dissatisfaction; Eating behavior; Weight control; Body weight; Adults. ResumenEn Latinoamérica se han realizado estudios dirigidos a evaluar la insatisfacción corporal y los comportamientos alimentarios anómalos (CAA), sin embargo se han enfocado principalmente en adolescentes o estudiantes univer- Revista Mexicana de Trastornos AlimentariosMexican Journal of Eating Disorders

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“…The benefits of regular physical activity (PA) on health and disease prevention are well recognized (15). PA reduces both morbidity and mortality and can minimize the physiological effects of an otherwise sedentary lifestyle increasing the active lifespan (16,17).…”

Section: Introductionmentioning

confidence: 99%

Impact of physical activity and sedentarism on hydration status and liquid intake in Spanish older adults. The PHYSMED study

et al. 2016

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Introduction: Data on hydration status in older adults are scarce and there are very few studies focusing on the impact of physical activity (PA) on drinking behavior. Objective: To assess the impact of physical activity and sedentarism on fl uid intake in Spanish elderly. Methods: 433 non-institutionalized Spanish older adults (58% females), aged 55-88 years, volunteered for the PHYSMED study. PA data were obtained by means of the Minnesota and EXERNET questionnaires. Population was divided into four groups: ILS (inactive and low sedentary), IHS (inactive and high sedentary), ALS (active and low sedentary) and AHS (active and high sedentary). Serum from fasting blood samples was analysed for osmolarity. Results: The mean of total liquid intake was 1,751 ± 628 mL/d. Signifi cant differences were observed for total liquid intake between ILS/ALS and IHS/ALS (p < 0.001). ALS subjects consumed a higher amount of beverages such as water, juice, milk, coffee, sport drink, beer, wine and distilled drinks than the other PA groups. There was a signifi cant difference for water intake between PA groups (p < 0.01). Serum osmolarity values were within references ranges in all subjects, and there was a signifi cant difference between PA groups (p < 0.01). Conclusions: Spanish older adults meet the DACH recommendations set by the German, Austrian and Swiss nutrition societies' liquid intake recommendations in the mean independently of PA and sedentary level. All participants are within reference ranges of serum osmolarity. Subjects in the active and low sedentary group consumed higher amounts of water and other beverages than in the other PA groups.

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Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Cited by 365 publications

References 56 publications

Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges

Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges

Body dissatisfaction and abnormal eating behaviors in a community sample of Chilean adults / Insatisfacción corporal y comportamientos alimentarios anómalos en una muestra comunitaria de adultos chilenos

Impact of physical activity and sedentarism on hydration status and liquid intake in Spanish older adults. The PHYSMED study

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