Abstract:We are exploring the effects of recently discovered (Götz, et al., (2011) Am. J. Hum. Genet. 88, 635) pathogenic mutations in human mitochondrial alanyl‐tRNA synthetase (mt AlaRS) on tRNA recognition and enzymatic function. These authors found an R592W mutation in multiple patients with severe infantile cardiomyopathy. R592 lies within the editing domain of mt AlaRS, but is distal to the aminoacyl editing active site. To characterize the editing function of mt AlaRS, we have constructed an editing‐defective C7… Show more
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