Understanding stem cells and its pivotal role in regenerative medicine

Sarkar, Arnab; Saha, Sanjukta; Paul, Abhik; Maji, Avik; Roy, Puspita Das; Maity, Tapan K.

doi:10.1016/j.lfs.2021.119270

Cited by 20 publications

(10 citation statements)

References 279 publications

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“…They are mainly expressed in bone marrow hematopoietic stem cells, among other stem cells, and are related to angiogenesis and inflammation. 3,4 Endogenous bone marrow stem cells could be mobilized to the damaged myocardium after MI. 5 C-kit + or Sca-1 + cells may play an important role after myocardial injury, suggesting that endogenous stem cells expressing c-kit or Sca-1 may participate in myocardial remodeling and functional recovery by reducing apoptosis and increasing angiogenesis.…”

Section: Electroacupuncture Improves Cardiac Function After Myocardia...mentioning

confidence: 99%

Electroacupuncture improves cardiac function after myocardial infarction by regulating the mobilization and migration of endogenous stem cells

et al. 2023

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Objective: The aim of this study was to explore the role and mechanisms of electroacupuncture (EA) in the regulation of chemokines in endogenous stem cell mobilization and myocardial regeneration after myocardial infarction (MI). Methods: An MI model was constructed in adult male Sprague-Dawley rats by ligating the left anterior descending coronary artery. After 4 weeks of treatment, echocardiography was used to detect changes in cardiac function, and Masson’s trichrome staining was used to detect collagen deposition. In addition, immunofluorescence staining was applied to examine von Willebrand factor (vWF)-positive vessels, the expression of cardiac troponin T (cTnT) and proliferation marker Ki67, and the number of c-kit-positive, C-X-C chemokine receptor type 4 (CXCR4)-positive, and Sca-1-positive endogenous stem cells in the infarcted area. In addition, the expression of stromal cell-derived factor (SDF)-1 and stem cell factor (SCF) was detected. Results: EA increased the ejection fraction after MI, reduced collagen deposition and cellular apoptosis, and increased the number of blood vessels compared with an untreated model group. EA significantly promoted cellular proliferation, except for myocardial cells, and significantly increased the number of c-kit-, CXCR4- and Sca-1-positive stem cells. Moreover, the expression of SDF-1 and SCF in myocardial tissue in the EA group was significantly higher than that in the (untreated) MI group. Conclusions: EA appears to promote angiogenesis and reduce collagen deposition, thus improving the cardiac function of rats with MI. The underlying mechanism of action may involve endogenous stem cell mobilization mediated by SDF-1/CXCR4 and SCF/c-kit.

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Section: Electroacupuncture Improves Cardiac Function After Myocardia...mentioning

confidence: 99%

Electroacupuncture improves cardiac function after myocardial infarction by regulating the mobilization and migration of endogenous stem cells

et al. 2023

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“…Currently, stem cell strategies include mainly exogenous stem cell transplantation and endogenous stem cell mobilization and regulation. After arriving at the site of injury, stem cells from different sources play mainly a regenerative and repair role by integrating defects, secreting a variety of bioactive molecules, and partaking in immune regulation ( Sarkar et al, 2021 ).…”

Section: Stem Cell Strategies Combining Aptamers In Regenerative Medi...mentioning

confidence: 99%

Application of aptamers in regenerative medicine

Zhang

Chen

Zhou

et al. 2022

Front. Bioeng. Biotechnol.

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Regenerative medicine is a discipline that studies how to use biological and engineering principles and operation methods to repair and regenerate damaged tissues and organs. Until now, regenerative medicine has focused mainly on the in-depth study of the pathological mechanism of diseases, the further development and application of new drugs, and tissue engineering technology strategies. The emergence of aptamers has supplemented the development methods and types of new drugs and enriched the application elements of tissue engineering technology, injecting new vitality into regenerative medicine. The role and application status of aptamers screened in recent years in various tissue regeneration and repair are reviewed, and the prospects and challenges of aptamer technology are discussed, providing a basis for the design and application of aptamers in long-term transformation.

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“…Stem cells are undifferentiated but capable of self-renewal and differentiation into various somatic cell types [33] . Stem cells have found application in drug development, disease modeling and regenerative medicine [34] ; in particular, they have been used in the treatment of several diseases, including diabetes, cancer, neurological and cardiovascular disorders [35] . They can be classified according to their potency (totipotent, pluripotent, multipotent, oligopotent, and unipotent) or their origin (embryonic, adult, tissue-resident, and induced pluripotent) [35] .…”

Section: Pluripotent Stem Cells In Dmmentioning

confidence: 99%

Pluripotent stem cells: a new strategy for the treatment of diabetes

Falsetti

Palmini

Aurilia

et al. 2022

International Journal of Bone Fragility

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Diabetes is now one of the most prevalent diseases in the world. Over the next twenty years, the number of affected individuals could reach 693 million. Diabetes is a group of chronic carbohydrate metabolism disorders responsible for increased blood glucose levels. It has several effects on the human body, and over the years can even become disabling, greatly impacting the patient’s quality of life. The most common therapy is based on daily and chronic administration of exogenous insulin, but this is associated with a series of dangerous and potentially fatal complications. Unsurprisingly therefore, over time, studies have explored various alternatives for the treatment of diabetes, not involving the use of insulin, primarily transplantation of the whole pancreas and of the islets of Langerhans. However, neither of these solutions can be applied on a large scale, mainly due to the lack of donors. In recent years, a viable alternative to insulin and to transplantation has emerged through exploration of the use of pluripotent stem cells and their properties. In this review we analyze the state of the art in this field, and the advantages and disadvantages of cell therapies used for reconstruction of the functional unit of the pancreas, the islets of Langerhans.

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Understanding stem cells and its pivotal role in regenerative medicine

Cited by 20 publications

References 279 publications

Electroacupuncture improves cardiac function after myocardial infarction by regulating the mobilization and migration of endogenous stem cells

Electroacupuncture improves cardiac function after myocardial infarction by regulating the mobilization and migration of endogenous stem cells

Application of aptamers in regenerative medicine

Pluripotent stem cells: a new strategy for the treatment of diabetes

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